Tuberculist information
Gene namedgt
Protein functionProbable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2622.46
Molecular mass(da)46879.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 431
	  		  	1    VSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRARVLHSAALRRLADKTQV   60
			  	61   VGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGLAHDIGHPPYGHNGERALD  120
			  	121  EVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTRASLDAVTKYPWMRGDGLGSQ  180
			  	181  RRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADDVAYSVHDVEDGVVSERIDLRVL  240
			  	241  AAEEDAAALARLGEREFSRVSADELMAAARRLSRLPVVAAVGKYDATLSASVALKRLTSE  300
			  	301  LVGRFASAAIATTRAAAGPGPLVRFRADLQVPDLVRAEVAVLKILALQFIMSDPRHLETQ  360
			  	361  ARQRERIHRVAHRLYSGAPQTLDPVYAAAFNTAADDAARLRVVVDQIASYTEGRLERIDA  420
			  	421  DQLGVSRNALD
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HDPF0196672-222
HD_assocPF13286329-420
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profile1.10.3210.10, 1.10.3410.10, 1.10.3550.10
Click for model details
zscore35.89
Residue begin6
Residue end425
Model Number2
Profile1.10.3410.10
Click for model details
zscore8.47
Residue begin209
Residue end310
Model Number3
Profile1.10.3550.10
Click for model details
zscore8.02
Residue begin315
Residue end428
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2344cGene nameConfidence Score
Rv2343cdnaG0.974
Rv2343cdnaG0.974
Rv2343cdnaG0.974
Rv2343cdnaG0.974
Rv2343cdnaG0.974
Rv1629polA0.942
Rv1629polA0.942
Rv1629polA0.942
Rv1547dnaE10.934
Rv1547dnaE10.934
Rv1547dnaE10.934
Rv1547dnaE10.934
Rv2445cndkA0.929
Rv1617pykA0.918
Rv1617pykA0.918
Rv3721cdnaZX0.917
Rv3721cdnaZX0.917
Rv0002dnaN0.905
Rv0002dnaN0.905
Rv0002dnaN0.905
Rv1021Rv10210.904
Rv3307deoD0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
triphosphoric acidPubChem0.932257.955
desoxyguanosinePubChem0.9267.241
protiumPubChem0.92.01576
deoxyguanosine triphosphatePubChem0.9507.181
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
deoxyguanosinePubChem0.9267.241
deuteriumPubChem0.92.01588