Rv3010c

Tuberculist information
Gene namepfkA
Protein functionProbable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3368.82
Molecular mass(da)36880
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 343
	  		  	1    MRIGVLTGGGDCPGLNAVIRAVVRTCHARYGSSVVGFQNGFRGLLENRRVQLHNDDRNDR   60
			  	61   LLAKGGTMLGTARVHPDKLRAGLPQIMQTLDDNGIDVLIPIGGEGTLTAASWLSEENVPV  120
			  	121  VGVPKTIDNDIDCTDVTFGHDTALTVATEAIDRLHSTAESHERVMLVEVMGRHAGWIALN  180
			  	181  AGLASGAHMTLIPEQPFDIEEVCRLVKGRFQRGDSHFICVVAEGAKPAPGTIMLREGGLD  240
			  	241  EFGHERFTGVAAQLAVEVEKRINKDVRVTVLGHIQRGGTPTAYDRVLATRFGVNAADAAH  300
			  	301  AGEYGQMVTLRGQDIGRVPLADAVRKLKLVPQSRYDDAAAFFG

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 1 to 300  |  Coverage: 87% PFK Range: 2 to 341  |  Coverage: 98% 1 Range: 1 to 343  |  Coverage: 99% 1
Number of amino acids : 343
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PFKPF003651-300
Mtb Structural Proteome models
Model Number1
Model nameRv3010c
Template3PFK    APDBCREDO
Template coverage3_318
Template Identity(%)43.2
Model coverage(%)98.8
Normalized DOPE score-0.738

Structure Models from Chopin
Model Number1
Profilec.89.1.1
Click for model details
zscore61.68
Residue begin1
Residue end343
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3010cGene nameConfidence Score
Rv0946cpgi0.997
Rv1617pykA0.994
Rv1617pykA0.994
Rv0363cfba0.993
Rv1449ctkt0.987
Rv1449ctkt0.987
Rv1449ctkt0.987
Rv1023eno0.982
Rv1023eno0.982
Rv1437pgk0.972
Rv1448ctal0.972
Rv1438tpi0.97
Rv1099cglpX0.964
Rv1436gap0.96
Rv1436gap0.96
Rv2029cpfkB0.946
Rv0733adk0.924
Rv1844cgnd10.915
Rv1844cgnd10.915
Rv3255cmanA0.907
Rv2783cgpsI0.906
Rv2783cgpsI0.906
Rv2783cgpsI0.906
Rv2783cgpsI0.906
Rv2783cgpsI0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fructose 1,6-bisphosphatePubChem0.993340.116
fructose 6-phosphatePubChem0.984260.136
adenosine diphosphatePubChem0.98427.201
D-fructose 6-phosphatePubChem0.97260.136
D-fructose-6-phosphatePubChem0.967260.136
adenosine triphosphatePubChem0.965507.181
phosphatePubChem0.94596.9872
glucose-6-phosphatePubChem0.931260.136
glyceraldehyde-3-phosphatePubChem0.919170.058
glucose-6-PPubChem0.916260.136
D-glyceraldehyde-3-phosphatePubChem0.915170.058
fructose bisphosphatePubChem0.91340.116
dihydroxyacetone phosphatePubChem0.909170.058
D-fructose 1,6-bisphosphatePubChem0.904550.183
H(+)PubChem0.9022.01588
fructose-1,6-bis-PPubChem0.902492.477
deuteriumPubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
magnesiumPubChem0.86524.305
phosphoenolpyruvatePubChem0.784168.042
F-6PubChem0.78430.464
glycerolPubChem0.76792.0938
fructosePubChem0.755180.156
Na(+)PubChem0.71322.9898