Rv1844c

Tuberculist information
Gene namegnd1
Protein functionProbable 6-phosphogluconate dehydrogenase Gnd1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2093.73
Molecular mass(da)51547.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 485
	  		  	1    MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFV   60
			  	61   RSETIPEFLAALEKPRRVLIMVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMR  120
			  	121  REKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCT  180
			  	181  HIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYL  240
			  	241  VEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALS  300
			  	301  GSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWD  360
			  	361  ITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRGAVESAIDSWRRVVST  420
			  	421  AAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDR  480
			  	481  TEVPV

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 10 to 184  |  Coverage: 35% NAD_binding_2 Range: 188 to 477  |  Coverage: 59% 6PGD Range: 9 to 481  |  Coverage: 97% 1 Range: 5 to 485  |  Coverage: 98% 1 Range: 10 to 184  |  Coverage: 35% 2 Range: 443 to 477  |  Coverage: 7% 3
Number of amino acids : 485
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_2PF0344610-184
6PGDPF00393188-477
Mtb Structural Proteome models
Model Number1
Model nameRv1844c
Template2PGD    APDBCREDO
Template coverage1_473
Template Identity(%)50.3
Model coverage(%)97.3
Normalized DOPE score-1.07

Structure Models from Chopin
Model Number1
Profile1.10.1040.10, 1.20.5.320, 3.40.50.720
Click for model details
zscore94.99
Residue begin5
Residue end485
Model Number2
Profilec.2.1.6
Click for model details
zscore10.8
Residue begin10
Residue end184
Model Number3
Profile1.20.5.320
Click for model details
zscore9.81
Residue begin443
Residue end477
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1844cGene nameConfidence Score
Rv1445cdevB0.996
Rv1447czwf20.995
Rv1447czwf20.995
Rv1408rpe0.993
Rv1449ctkt0.978
Rv1449ctkt0.978
Rv1449ctkt0.978
Rv2465crpiB0.969
Rv1121zwf10.968
Rv1121zwf10.968
Rv1617pykA0.953
Rv1617pykA0.953
Rv1023eno0.944
Rv1023eno0.944
Rv0946cpgi0.932
Rv3010cpfkA0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
6-phosphogluconatePubChem0.996276.135
NADPPubChem0.996744.413
ribulose 5-phosphatePubChem0.983230.11
ribulose-5-phosphatePubChem0.982230.11
6-phosphoglucono-delta-lactonePubChem0.952258.12
NADP(H)PubChem0.936745.421
carbon dioxidePubChem0.91544.0095
hydroxyl radicalsPubChem0.90317.0073
protiumPubChem0.92.01576
D-xylulose 5-phosphatePubChem0.9230.11
deuteriumPubChem0.92.01588
D-ribose 5-phosphatePubChem0.9230.11
H(+)PubChem0.92.01588
reduced glutathionePubChem0.811307.323
phosphatePubChem0.80796.9872
chloridePubChem0.79235.453
sulfatePubChem0.77896.0626
hydron sulfatePubChem0.778196.157
4-phospho-D-erythronohydroxamic acidPubChem0.773231.098
5'-diphosphoadenosine 2'-phosphatePubChem0.772507.181
2',5'-ADPPubChem0.766427.201
S-p-nitrobenzyloxycarbonylglutathionePubChem0.758488.469
gluconatePubChem0.749196.155
UDP-N-acetylglucosamine enolpyruvatePubChem0.736677.4
sultamicillinPubChem0.72594.657
glucose-6-phosphatePubChem0.706260.136