Rv1121

Tuberculist information
Gene namezwf1
Protein functionProbable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1243.71
Molecular mass(da)52155.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 466
	  		  	1    LVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWA   60
			  	61   RESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFA  120
			  	121  PIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVE  180
			  	181  LEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL  240
			  	241  VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALR  300
			  	301  TEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDP  360
			  	361  GMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWR  420
			  	421  IVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 32 to 215  |  Coverage: 39% G6PD_N Range: 217 to 514  |  Coverage: 63% G6PD_C Range: 10 to 455  |  Coverage: 95% 1
Number of amino acids : 466
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
G6PD_NPF0047932-215
G6PD_CPF02781217-514
Mtb Structural Proteome models
Model Number1
Model nameRv1121
Template1DPG    APDBCREDO
Template coverage6_481
Template Identity(%)31.2
Model coverage(%)95.5
Normalized DOPE score-0.657

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1121Gene nameConfidence Score
Rv1445cdevB0.998
Rv0946cpgi0.993
Rv1122gnd20.983
Rv1122gnd20.983
Rv1844cgnd10.968
Rv1844cgnd10.968
Rv1449ctkt0.918
Rv1449ctkt0.918
Rv1449ctkt0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.975744.413
glucose-6-phosphatePubChem0.971260.136
glucose-6-PPubChem0.962260.136
6-phosphogluconatePubChem0.951276.135
NADP(H)PubChem0.939745.421
6-phosphoglucono-delta-lactonePubChem0.917258.12
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588