Rv1447c

Tuberculist information
Gene namezwf2
Protein functionProbable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1625.42
Molecular mass(da)57343
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 514
	  		  	1    MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPP   60
			  	61   TFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQ  120
			  	121  LAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGH  180
			  	181  DLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI  240
			  	241  TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSAT  300
			  	301  RLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPF  360
			  	361  YLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPG  420
			  	421  TAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH  480
			  	481  WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 13 to 180  |  Coverage: 32% G6PD_N Range: 182 to 457  |  Coverage: 53% G6PD_C Range: 29 to 511  |  Coverage: 93% 1 Range: 31 to 316  |  Coverage: 55% 1
Number of amino acids : 514
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
G6PD_NPF0047913-180
G6PD_CPF02781182-457
Mtb Structural Proteome models
Model Number1
Model nameRv1447c
Template2BH9    APDBCREDO
Template coverage32_503
Template Identity(%)37.7
Model coverage(%)93.6
Normalized DOPE score-0.502

Structure Models from Chopin
Model Number1
Profilec.1.15.1 - 3.20.20.150
Click for model details
zscore7.42
Residue begin31
Residue end316
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1447cGene nameConfidence Score
Rv1445cdevB0.999
Rv1844cgnd10.995
Rv1844cgnd10.995
Rv0946cpgi0.995
Rv1449ctkt0.991
Rv1449ctkt0.991
Rv1449ctkt0.991
Rv1448ctal0.988
Rv1122gnd20.946
Rv1122gnd20.946
Rv1408rpe0.911
Rv1617pykA0.908
Rv1617pykA0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.992744.413
glucose-6-phosphatePubChem0.99260.136
glucose-6-PPubChem0.987260.136
6-phosphogluconatePubChem0.976276.135
NADP(H)PubChem0.967745.421
6-phosphoglucono-delta-lactonePubChem0.939258.12
deuteriumPubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
phosphatePubChem0.86896.9872
dehydroepiandrosteronePubChem0.784288.424
NAD+PubChem0.716663.425
glycerolPubChem0.71592.0938