Rv1099c

Tuberculist information
Gene nameglpX
Protein functionFructose 1,6-bisphosphatase GlpX
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1227.6
Molecular mass(da)38084
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 362
	  		  	1    MTAEGSGSSTAAVASHDPSHTRPSRREAPDRNLAMELVRVTEAGAMAAGRWVGRGDKEGG   60
			  	61   DGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGTTL  120
			  	121  MSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKD  180
			  	181  LSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGT  240
			  	241  PEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATG  300
			  	301  VTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAVYP  360
			  	361  LP

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 30 to 338  |  Coverage: 85% FBPase_glpX Range: 1 to 308  |  Coverage: 84% 1 Range: 1 to 308  |  Coverage: 84% 1
Number of amino acids : 362
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FBPase_glpXPF0332030-338
Mtb Structural Proteome models
Model Number1
Model nameRv1099c
Template1NI9    APDBCREDO
Template coverage7_326
Template Identity(%)45.4
Model coverage(%)84.8
Normalized DOPE score-0.547

Structure Models from Chopin
Model Number1
Profilee.7.1.2
Click for model details
zscore59.22
Residue begin1
Residue end308
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1099cGene nameConfidence Score
Rv1449ctkt0.991
Rv1449ctkt0.991
Rv1449ctkt0.991
Rv3696cglpK0.982
Rv3696cglpK0.982
Rv0363cfba0.976
Rv3010cpfkA0.964
Rv0946cpgi0.959
Rv1097cRv1097c0.956
Rv2029cpfkB0.947
Rv1448ctal0.941
Rv1100Rv11000.941
Rv1408rpe0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fructose 1,6-bisphosphatePubChem0.994340.116
D-fructose-6-phosphatePubChem0.9260.136
D-fructose 6-phosphatePubChem0.9260.136
magnesiumPubChem0.7624.305