Rv3696c

Tuberculist information
Gene nameglpK
Protein functionProbable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4138.2
Molecular mass(da)55827.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 517
	  		  	1    VSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQILPRAGWVEHNP   60
			  	61   VEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVWNRHTGRPYYNAIVWQDTRTD  120
			  	121  RIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVDGVRAAAENGDALFGTPDTWV  180
			  	181  LWNLTGGPRGGVHVTDVTNASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEPY  240
			  	241  GVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSNN  300
			  	301  GLLTTVCYQFGNAKPVYALEGSIAVTGSAVQWLRDQLGIISGAAQSEALARQVPDNGGMY  360
			  	361  FVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLARATLEAICYQSRDVVDAMEADSGVRL  420
			  	421  QVLKVDGGITGNDLCMQIQADVLGVDVVRPVVAETTALGVAYAAGLAVGFWAAPSDLRAN  480
			  	481  WREDKRWTPTWDDDERAAGYAGWRKAVQRTLDWVDVS

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 16 to 268  |  Coverage: 48% FGGY_N Range: 277 to 468  |  Coverage: 36% FGGY_C Range: 16 to 513  |  Coverage: 96% 1 Range: 14 to 271  |  Coverage: 49% 1
Number of amino acids : 517
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FGGY_NPF0037016-268
FGGY_CPF02782277-468
Mtb Structural Proteome models
Model Number1
Model nameRv3696c
Template1BU6    OPDBCREDO
Template coverage5_496
Template Identity(%)53.0
Model coverage(%)96.1
Normalized DOPE score-0.74

Structure Models from Chopin
Model Number1
Profilec.55.1.4
Click for model details
zscore56.66
Residue begin14
Residue end271
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3696cGene nameConfidence Score
Rv3302cglpD20.989
Rv2249cglpD10.987
Rv1099cglpX0.982
Rv1617pykA0.967
Rv1617pykA0.967
Rv2482cplsB20.943
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerolPubChem0.99892.0938
glycerol-3-phosphatePubChem0.992172.074
adenosine diphosphatePubChem0.979427.201
fructose 1,6-bisphosphatePubChem0.915340.116
deuteriumPubChem0.9132.01588
H(+)PubChem0.9092.01588
glycerol 1-phosphatePubChem0.907172.074
adenosine triphosphatePubChem0.901507.181
protiumPubChem0.92.01576
chloridePubChem0.8135.453
phosphatePubChem0.80696.9872
ethylene glycol; hydronPubChem0.78863.0758
polyethylene glycolPubChem0.78862.0678
hydron diphosphatePubChem0.784391.981
magnesiumPubChem0.77524.305
zincPubChem0.75265.409
glycerol 3-phosphatePubChem0.748249.03
Na(+)PubChem0.7322.9898
D-glyceraldehyde-3-phosphatePubChem0.729170.058
dihydroxyacetonePubChem0.70890.0779