Rv2249c

Tuberculist information
Gene nameglpD1
Protein functionProbable glycerol-3-phosphate dehydrogenase GlpD1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2523.24
Molecular mass(da)54143.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 516
	  		  	1    VLMPHSAALNAARRSADLTALADGGALDVIVIGGGITGVGIALDAATRGLTVALVEKHDL   60
			  	61   AFGTSRWSSKLVHGGLRYLASGNVGIARRSAVERGILMTRNAPHLVHAMPQLVPLLPSMG  120
			  	121  HTKRALVRAGFLAGDALRVLAGTPAATLPRSRRIPASRVVEIAPTVRRDGLDGGLLAYDG  180
			  	181  QLIDDARLVMAVARTAAQHGARILTYVGASNVTGTSVELTDRRTRQSFALSARAVINAAG  240
			  	241  VWAGEIDPSLRLRPSRGTHLVFDAKSFANPTAALTIPIPGELNRFVFAMPEQLGRIYLGL  300
			  	301  TDEDAPGPIPDVPQPSSEEITFLLDTVNTALGTAVGTKDVIGAYAGLRPLIDTGGAGVQG  360
			  	361  RTADVSRDHAVFESPSGVISVVGGKLTEYRYMAEDVLNRAITLRHLRAAKCRTRNLPLIG  420
			  	421  APANPGPAPGSGAGLPESLVARYGAEAANVAAAATCERPTEPVADGIDVTRAEFEYAVTH  480
			  	481  EGALDVDDILDRRTRIGLVPRDRERVVAVAKEFLSR

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 28 to 390  |  Coverage: 70% DAO Range: 24 to 416  |  Coverage: 75% 1 Range: 1 to 284  |  Coverage: 54% 1
Number of amino acids : 516
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DAOPF0126628-390
Mtb Structural Proteome models
Model Number1
Model nameRv2249c
Template1RYI    APDBCREDO
Template coverage2_361
Template Identity(%)17.2
Model coverage(%)75.8
Normalized DOPE score0.208

Structure Models from Chopin
Model Number1
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore7.27
Residue begin1
Residue end284
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2249cGene nameConfidence Score
Rv3696cglpK0.987
Rv3696cglpK0.987
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerol-3-phosphatePubChem0.952172.074
dihydroxyacetone phosphatePubChem0.949170.058
glycerol 1-phosphatePubChem0.9172.074