SInCRe - Rv2361c

Tuberculist information

Gene name	Rv2361c
Protein function	Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase)
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	2642.58
Molecular mass(da)	33759.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 296

	  		  	1    VARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPYGGPCRPPQHTSKAAAP   60
			  	61   RIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVIDIACGAIELGIKWLSLYAF  120
			  	121  STENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWVGSRPRLWRSVINELAVAEEM  180
			  	181  TKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLNPERITESTIARHLQRPDIPDVD  240
			  	241  LFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDRRDLWAACEEYASRTRRFGSA

Known structures in the PDB

	PDB ID	2VG2
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	1.95

	PDB ID	2VG3
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	1.8

	PDB ID	2VG4
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	2.6

	PDB ID	4ONC
	Total residue count	568
	Number of chains	2
	Method	X-RAY
	Resolution	1.83

Number of amino acids : 296

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Prenyltransf	PF01255	74-295

Mtb Structural Proteome models

Model Number	1
Model name	Rv2361c_2vg3_A
Template	2VG3 APDB CREDO
Template coverage	13_296
Template Identity(%)	100.0
Model coverage(%)	95.6
Normalized DOPE score	-1.936

Model Number	2
Model name	Rv2361c
Template	1F75 APDB CREDO
Template coverage	15_242
Template Identity(%)	37.5
Model coverage(%)	76.7
Normalized DOPE score	-0.833

Structure Models from Chopin

Model Number	1
Profile	c.101.1.1 - 3.40.1180.10 Click for model details
zscore	50.41
Residue begin	62
Residue end	293

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2361c	Gene name	Confidence Score
Rv2870c	dxr	0.948
Rv2870c	dxr	0.948
Rv2870c	dxr	0.948
Rv2890c	rpsB	0.941
Rv2883c	pyrH	0.938
Rv1086	Rv1086	0.936
Rv2158c	murE	0.921
Rv2158c	murE	0.921
Rv2158c	murE	0.921
Rv2881c	cdsA	0.907

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2361c_2vg3_A	3	3bjw_SVR_E_503 PDB CREDO	0.553	0.240	0.538	0.006
Rv2361c_2vg3_A	3	1uwj_BAX_A_1723 PDB CREDO	0.585	0.197	0.538	0.006
Rv2361c_2vg3_A	3	3nxu_RIT_B_600 PDB CREDO	0.536	0.264	0.536	0.006
Rv2361c_2vg3_A	3	3nxu_RIT_A_600 PDB CREDO	0.533	0.269	0.533	0.007
Rv2361c_2vg3_A	3	3bjw_SVR_B_501 PDB CREDO	0.585	0.197	0.526	0.007
Rv2361c_2vg3_A	3	1fap_RAP_A_108 PDB CREDO	0.538	0.261	0.524	0.008
Rv2361c_2vg3_A	3	3bjw_SVR_F_502 PDB CREDO	0.579	0.205	0.521	0.008
Rv2361c_2vg3_A	3	3bjw_SVR_B_512 PDB CREDO	0.578	0.206	0.520	0.008
Rv2361c_2vg3_A	3	3bjw_SVR_H_504 PDB CREDO	0.578	0.207	0.519	0.008
Rv2361c_2vg3_A	3	2vn1_FK5_A_501 PDB CREDO	0.528	0.276	0.514	0.009
Rv2361c_2vg3_A	3	1uob_PNN_A_1311 PDB CREDO	0.619	0.157	0.506	0.010
Rv2361c_2vg3_A	3	3kk6_CEL_B_1701 PDB CREDO	0.505	0.311	0.505	0.010
Rv2361c_2vg3_A	3	3d91_REM_A_350 PDB CREDO	0.596	0.184	0.502	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
isopentenyl diphosphatePubChem	0.999	246.092
geranyl diphosphatePubChem	0.997	314.209
farnesyl diphosphatePubChem	0.995	382.326
pyrophosphatePubChem	0.969	177.975
magnesiumPubChem	0.956	24.305
geranylgeranyl pyrophosphatePubChem	0.952	450.443
sulfatePubChem	0.946	96.0626
phosphatePubChem	0.941	96.9872
hydron; phosphonato phosphatePubChem	0.94	175.959
hydron diphosphatePubChem	0.939	391.981
hydron sulfatePubChem	0.939	196.157
trans,trans,cis-geranylgeranyl pyrophosphatePubChem	0.9	450.443
glycerolPubChem	0.9	92.0938
chloridePubChem	0.9	35.453
dimethylallyl diphosphatePubChem	0.832	246.092
undecaprenyl pyrophosphatePubChem	0.827	927.262
isoprenePubChem	0.813	68.117