SInCRe - Rv2881c

Tuberculist information

Gene name	cdsA
Protein function	Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase)
Functional category(tuberculist)	lipid metabolism
Gene location(kb)	3190.7
Molecular mass(da)	32002.9
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 306

	  		  	1    VTTNDAGTGNPAEQPARGAKQQPATETSRAGRDLRAAIVVGLSIGLVLIAVLVFVPRVWV   60
			  	61   AIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQAAVWLTWPFGAVGALAGFGGMVVVC  120
			  	121  MIWRLFMQDSVTRPTTGGAPSPGNYLSDVSATVFLAVWVPLFCSFGAMLVYPENGSGWVF  180
			  	181  CMMIAVIASDVGGYAVGVLFGKHPMVPTISPKKSWEGFAGSLVCGITATIITATFLVGKT  240
			  	241  PWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGRLLPGHGGLMDRLDGILPSAVAAWI  300
			  	301  VLTLLP

Known structures in the PDB

No Known structures

Number of amino acids : 306

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
CTP_transf_1	PF01148	35-305

Mtb Structural Proteome models

Structure models not available for this query

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

Structure models not available for this query

STRING

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Protein interacting with Rv2881c	Gene name	Confidence Score
Rv2746c	pgsA3	0.996
Rv1822	pgsA2	0.991
Rv2612c	pgsA1	0.981
Rv2882c	frr	0.98
Rv2182c	Rv2182c	0.971
Rv0436c	pssA	0.959
Rv2244	acpM	0.942
Rv2361c	Rv2361c	0.907
Rv2870c	dxr	0.902
Rv2870c	dxr	0.902
Rv2870c	dxr	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
deuteriumPubChem	0.9	2.01588
glycerol 1-phosphatePubChem	0.9	172.074
poly CPubChem	0.9	323.197
ara-CTPPubChem	0.9	483.156
H(+)PubChem	0.9	2.01588
glycerol-3-phosphatePubChem	0.9	172.074
Co-APubChem	0.9	767.534
pyrophosphatePubChem	0.9	177.975
protiumPubChem	0.9	2.01576
coenzyme APubChem	0.9	767.534
DL-serinePubChem	0.9	105.093
L-serinePubChem	0.9	105.093
cytidine triphosphatePubChem	0.9	483.156