Rv1080c

Tuberculist information
Gene namegreA
Protein functionProbable transcription elongation factor GreA (transcript cleavage factor GreA)
Functional category(tuberculist)information pathways
Gene location(kb)1205.3
Molecular mass(da)17854.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 164
	  		  	1    MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQ   60
			  	61   EARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSETFLIATRQEGVSDGKL  120
			  	121  EVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYHS

Known structures in the PDB
No Known structures
1 17 33 49 65 81 97 113 129 145 161 Range: 3 to 76  |  Coverage: 44% GreA_GreB_N Range: 81 to 161  |  Coverage: 48% GreA_GreB Range: 9 to 134  |  Coverage: 76% 1 Range: 4 to 162  |  Coverage: 96% 1 Range: 4 to 82  |  Coverage: 47% 2 Range: 79 to 162  |  Coverage: 50% 3
Number of amino acids : 164
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GreA_GreB_NPF034493-76
GreA_GreBPF0127281-161
Mtb Structural Proteome models
Model Number1
Model nameRv1080c
Template1GRJ    APDBCREDO
Template coverage6_131
Template Identity(%)41.3
Model coverage(%)76.2
Normalized DOPE score-0.748

Structure Models from Chopin
Model Number1
Profilea.2.1.1, d.26.1.2
Click for model details
zscore27.45
Residue begin4
Residue end162
Model Number2
Profilea.2.1.1
Click for model details
zscore21.19
Residue begin4
Residue end82
Model Number3
Profiled.26.1.2
Click for model details
zscore15.23
Residue begin79
Residue end162
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1080cGene nameConfidence Score
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv0667rpoB0.95
Rv1384carB0.942
Rv1384carB0.942
Rv1384carB0.942
Rv1384carB0.942
Rv1383carA0.941
Rv1383carA0.941
Rv0639nusG0.941
Rv0639nusG0.941
Rv0683rpsG0.941
Rv2783cgpsI0.915
Rv2783cgpsI0.915
Rv2783cgpsI0.915
Rv2783cgpsI0.915
Rv2783cgpsI0.915
Rv0668rpoC0.913
Rv0668rpoC0.913
Rv0668rpoC0.913
Rv0668rpoC0.913
Rv0668rpoC0.913
Rv1292argS0.908
Rv1292argS0.908
Rv1292argS0.908
Rv2462ctig0.906
Rv2462ctig0.906
Rv0651rplJ0.906
Rv2462ctig0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
WCCPubChem0.73366.584
GREPubChem0.712354.782