Rv2793c

Tuberculist information
Gene nametruB
Protein functionProbable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase)
Functional category(tuberculist)information pathways
Gene location(kb)3102.36
Molecular mass(da)31819.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 298
	  		  	1    MSATGPGIVVIDKPAGMTSHDVVGRCRRIFATRRVGHAGTLDPMATGVLVIGIERATKIL   60
			  	61   GLLTAAPKSYAATIRLGQTTSTEDAEGQVLQSVPAKHLTIEAIDAAMERLRGEIRQVPSS  120
			  	121  VSAIKVGGRRAYRLARQGRSVQLEARPIRIDRFELLAARRRDQLIDIDVEIDCSSGTYIR  180
			  	181  ALARDLGDALGVGGHVTALRRTRVGRFELDQARSLDDLAERPALSLSLDEACLLMFARRD  240
			  	241  LTAAEASAAANGRSLPAVGIDGVYAACDADGRVIALLRDEGSRTRSVAVLRPATMHPG

Known structures in the PDB
PDB ID1SGV
Total residue count632
Number of chains2
MethodX-RAY
Resolution1.9
1 30 59 88 117 146 175 204 233 262 291 Range: 27 to 179  |  Coverage: 51% TruB_N Range: 236 to 291  |  Coverage: 18% TruB_C Range: 3 to 292  |  Coverage: 96% 1 Range: 3 to 292  |  Coverage: 96% 2 Range: 1 to 251  |  Coverage: 83% 1
Number of amino acids : 298
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TruB_NPF0150927-179
TruB_CPF09142236-291
Mtb Structural Proteome models
Model Number1
Model nameRv2793c_1sgv_A
Template1SGV    APDBCREDO
Template coverage3_292
Template Identity(%)100.0
Model coverage(%)96.7
Normalized DOPE score-1.122

Model Number2
Model nameRv2793c
Template1SGV    APDBCREDO
Template coverage3_292
Template Identity(%)100.0
Model coverage(%)96.7
Normalized DOPE score-0.313

Structure Models from Chopin
Model Number1
Profiled.265.1.2
Click for model details
zscore45.5
Residue begin1
Residue end251
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2793cGene nameConfidence Score
Rv2785crpsO0.997
Rv2839cinfB0.988
Rv2839cinfB0.988
Rv2839cinfB0.988
Rv2839cinfB0.988
Rv2783cgpsI0.983
Rv2783cgpsI0.983
Rv2783cgpsI0.983
Rv2783cgpsI0.983
Rv1711Rv17110.983
Rv2783cgpsI0.983
Rv1711Rv17110.983
Rv3455ctruA0.981
Rv1010ksgA0.973
Rv2786cribF0.965
Rv2786cribF0.965
Rv1540Rv15400.962
Rv1540Rv15400.962
Rv2906ctrmD0.96
Rv2838crbfA0.957
Rv1392metK0.944
Rv1392metK0.944
Rv1392metK0.944
Rv1165typA0.942
Rv1165typA0.942
Rv1165typA0.942
Rv1649pheS0.941
Rv1649pheS0.941
Rv2842cRv2842c0.934
Rv0719rplF0.925
Rv2404clepA0.924
Rv2404clepA0.924
Rv2404clepA0.924
Rv2404clepA0.924
Rv0718rpsH0.923
Rv2883cpyrH0.914
Rv3459crpsK0.911
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pseudouridinePubChem0.908244.201
uridinePubChem0.829244.201
zincPubChem0.79865.409
[5-(5-fluoro-4-hydroxy-2,6-dioxo-1,3-diazinan-5-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phospPubChem0.794360.187
potassiumPubChem0.75239.0983
potassium hydridePubChem0.75240.1062
magnesiumPubChem0.71724.305