Rv1165

Tuberculist information
Gene nametypA
Protein functionPossible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein)
Functional category(tuberculist)information pathways
Gene location(kb)1294.17
Molecular mass(da)67548.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 628
	  		  	1    VPFRNVAIVAHVDHGKTTLVDAMLRQSGALRERGELQERVMDTGDLEREKGITILAKNTA   60
			  	61   VHRHHPDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKAL  120
			  	121  AAHLPVILVVNKTDRPDARIAEVVDASHDLLLDVASDLDDEAAAAAEHALGLPTLYASGR  180
			  	181  AGVASTTAPPDGQVPDGTNLDPLFEVLEKHVPPPKGEPDAPLQALVTNLDASTFLGRLAL  240
			  	241  IRIYNGRIRKGQQVAWIRQVDGQQTVTTAKITELLATEGVERKPTDAAVAGDIVAVAGLP  300
			  	301  EIMIGDTLAASANPVALPRITVDEPAISVTIGTNTSPLAGKVGGHKLTARMVRSRLDAEL  360
			  	361  VGNVSIRVVDIGAPDAWEVQGRGELALAVLVEQMRREGFELTVGKPQVVTKTIDGTLHEP  420
			  	421  FESMTVDCPEEYIGAVTQLMAARKGRMVEMANHTTGWVRMDFVVPSRGLIGWRTDFLTET  480
			  	481  RGSGVGHAVFDGYRPWAGEIRARHTGSLVSDRAGAITPFALLQLADRGQFFVEPGQQTYE  540
			  	541  GMVVGINPRPEDLDINVTREKKLTNMRSSTADVIETLAKPLQLDLERAMELCAPDECVEV  600
			  	601  TPEIVRIRKVELAAAARARSRARTKARG

Known structures in the PDB
No Known structures
1 63 125 187 249 311 373 435 497 559 621 Range: 1 to 213  |  Coverage: 33% GTP_EFTU Range: 236 to 309  |  Coverage: 11% GTP_EFTU_D2 Range: 416 to 504  |  Coverage: 14% EFG_C Range: 1 to 582  |  Coverage: 92% 1 Range: 322 to 621  |  Coverage: 47% 1 Range: 1 to 628  |  Coverage: 99% 2 Range: 503 to 578  |  Coverage: 11% 3 Range: 416 to 504  |  Coverage: 14% 4 Range: 1 to 213  |  Coverage: 33% 5 Range: 322 to 409  |  Coverage: 13% 6
Number of amino acids : 628
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_EFTUPF000091-213
GTP_EFTU_D2PF03144236-309
EFG_CPF00679416-504
Mtb Structural Proteome models
Model Number1
Model nameRv1165
Template1G7S    APDBCREDO
Template coverage3_585
Template Identity(%)19.4
Model coverage(%)92.5
Normalized DOPE score1.039

Structure Models from Chopin
Model Number1
Profile2.40.50.250, 3.30.70.240, 3.30.70.870
Click for model details
zscore63.04
Residue begin322
Residue end621
Model Number2
Profileb.43.3.1, c.37.1.8, d.14.1.1, d.58.11.1 - 2.40.30.10, 3.30.70.870, 3.40.50.300
Click for model details
zscore32.43
Residue begin1
Residue end628
Model Number3
Profile2.40.50.250
Click for model details
zscore20.09
Residue begin503
Residue end578
Model Number4
Profile3.30.70.240
Click for model details
zscore17.32
Residue begin416
Residue end504
Model Number5
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore9.85
Residue begin1
Residue end213
Model Number6
Profile3.30.70.870
Click for model details
zscore9.69
Residue begin322
Residue end409
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1165Gene nameConfidence Score
Rv2793ctruB0.942
Rv2793ctruB0.942
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions