Rv2373c

Tuberculist information
Gene namednaJ2
Protein functionProbable chaperone protein DnaJ2
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2652.84
Molecular mass(da)40456.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 382
	  		  	1    VARDYYGLLGVSKNASDADIKRAYRKLARELHPDVNPDEAAQAKFKEISVAYEVLSDPDK   60
			  	61   RRIVDLGGDPLESAAAGGNGFGGFGGLGDVFEAFFGGGFGGGAASRGPIGRVRPGSDSLL  120
			  	121  RMRLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSVPIPCDTCGGRGEVQTVQRSLLG  180
			  	181  QMLTSRPCPTCRGVGVVIPDPCQQCMGDGRIRARREISVKIPAGVGDGMRVRLAAQGEVG  240
			  	241  PGGGPAGDLYVEVHEQAHDVFVREGDHLHCTVSVPMVDAALGVTVTVDAILDGLSEITIP  300
			  	301  PGTQPGSVITLRGRGMPHLRSNTRGDLHVHVEVVVPTRLDHQDIELLRELKGRRDREVAE  360
			  	361  VRSTHAAAGGLFSRLRETFTGR

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 4 to 65  |  Coverage: 15% DnaJ Range: 145 to 209  |  Coverage: 16% DnaJ_CXXCXGXG Range: 267 to 346  |  Coverage: 20% DnaJ_C Range: 6 to 68  |  Coverage: 16% 1 Range: 4 to 74  |  Coverage: 18% 2 Range: 1 to 74  |  Coverage: 19% 3 Range: 112 to 337  |  Coverage: 58% 4 Range: 145 to 209  |  Coverage: 16% 1 Range: 1 to 47  |  Coverage: 12% 2 Range: 4 to 65  |  Coverage: 15% 3 Range: 211 to 257  |  Coverage: 12% 4 Range: 267 to 313  |  Coverage: 12% 5
Number of amino acids : 382
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DnaJPF002264-65
DnaJ_CXXCXGXGPF00684145-209
DnaJ_CPF01556267-346
Mtb Structural Proteome models
Model Number1
Model nameRv2373c.3
Template2CTW    APDBCREDO
Template coverage20_83
Template Identity(%)54.0
Model coverage(%)16.2
Normalized DOPE score-1.484

Model Number2
Model nameRv2373c.2
Template2CUG    APDBCREDO
Template coverage18_88
Template Identity(%)53.5
Model coverage(%)18.3
Normalized DOPE score-1.364

Model Number3
Model nameRv2373c.1
Template1WJZ    APDBCREDO
Template coverage14_94
Template Identity(%)31.1
Model coverage(%)19.1
Normalized DOPE score-1.096

Model Number4
Model nameRv2373c
Template1NLT    APDBCREDO
Template coverage110_337
Template Identity(%)24.3
Model coverage(%)58.9
Normalized DOPE score0.392

Structure Models from Chopin
Model Number1
Profileg.54.1.1 - 2.10.230.10
Click for model details
zscore14.95
Residue begin145
Residue end209
Model Number2
Profileb.4.1.1, g.54.1.1 - 2.10.230.10, 2.60.260.20
Click for model details
zscore11.6
Residue begin1
Residue end47
Model Number3
Profilea.2.3.1 - 1.10.287.110
Click for model details
zscore9.22
Residue begin4
Residue end65
Model Number4
Profileb.4.1.1
Click for model details
zscore8.61
Residue begin211
Residue end257
Model Number5
Profileb.4.1.1
Click for model details
zscore8.61
Residue begin267
Residue end313
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2373cGene nameConfidence Score
Rv0350dnaK0.998
Rv2374chrcA0.975
Rv2374chrcA0.975
Rv0351grpE0.969
Rv2372cRv2372c0.94
Rv0384cclpB0.934
Rv0384cclpB0.934
Rv0384cclpB0.934
Rv0384cclpB0.934
Rv0352dnaJ10.934
Rv0352dnaJ10.934
Rv0352dnaJ10.934
Rv2299chtpG0.929
Rv2299chtpG0.929
Rv3024ctrmU0.926
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2373c.164dta_ADN_A_401PDBCREDO0.5550.2380.5300.007
Rv2373c.212y7j_B49_B_1294PDBCREDO0.5450.2510.5230.008
Rv2373c.212zva_1N1_A_513PDBCREDO0.5530.2400.5100.009
Rv2373c.161xwf_ADN_D_433PDBCREDO0.5320.2690.5090.009
Rv2373c.161xwf_ADN_A_433PDBCREDO0.5270.2770.5040.010
Rv2373c.161xwf_ADN_C_433PDBCREDO0.5270.2770.5040.010
Rv2373c.212y7j_B49_D_1294PDBCREDO0.5970.1830.5030.010
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions