Rv3024c

Tuberculist information
Gene nametrmU
Protein functionProbable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU
Functional category(tuberculist)information pathways
Gene location(kb)3382.78
Molecular mass(da)38120.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 367
	  		  	1    MKVLAAMSGGVDSSVAAARMVDAGHEVVGVHMALSTAPGTLRTGSRGCCSKEDAADARRV   60
			  	61   ADVLGIPFYVWDFAEKFKEDVINDFVSSYARGETPNPCVRCNQQIKFAALSARAVALGFD  120
			  	121  TVATGHYARLSGGRLRRAVDRDKDQSYVLAVLTAQQLRHAAFPIGDTPKRQIRAEAARRG  180
			  	181  LAVANKPDSHDICFIPSGNTKAFLGERIGVRRGVVVDADGVVLASHDGVHGFTIGQRRGL  240
			  	241  GIAGPGPNGRPRYVTAIDADTATVHVGDVTDLDVQTLTGRAPVFTAGAAPSGPVDCVVQV  300
			  	301  RAHGETVSAVAELIGDALFVQLHAPLRGVARGQTLVLYRPDPAGDEVLGSATIAGASGLS  360
			  	361  TGGNPGA

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 1 to 353  |  Coverage: 95% tRNA_Me_trans Range: 2 to 227  |  Coverage: 61% 1 Range: 1 to 366  |  Coverage: 99% 1 Range: 207 to 275  |  Coverage: 18% 2 Range: 41 to 181  |  Coverage: 38% 3
Number of amino acids : 367
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_Me_transPF030541-353
Mtb Structural Proteome models
Model Number1
Model nameRv3024c
Template2C5S    APDBCREDO
Template coverage179_391
Template Identity(%)17.1
Model coverage(%)61.1
Normalized DOPE score0.654

Structure Models from Chopin
Model Number1
Profile2.30.30.280, 2.40.30.10, 3.40.50.620
Click for model details
zscore58.61
Residue begin1
Residue end366
Model Number2
Profile2.30.30.280
Click for model details
zscore14.35
Residue begin207
Residue end275
Model Number3
Profilec.26.2.6
Click for model details
zscore8.55
Residue begin41
Residue end181
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3024cGene nameConfidence Score
Rv3025ciscS0.998
Rv2906ctrmD0.929
Rv2373cdnaJ20.926
Rv2373cdnaJ20.926
Rv2373cdnaJ20.926
Rv2727cmiaA0.917
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions