Rv0091

Tuberculist information
Gene namemtn
Protein functionProbable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)99.684
Molecular mass(da)27339.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 255
	  		  	1    MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAAGMGKVNTGLT   60
			  	61   ATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGLLTDERLRPYQPGHIPF  120
			  	121  IEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGRQPRIYYGTILTGDQYLHCER  180
			  	181  TRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAAS  240
			  	241  SARVLLRLLPVLTAC

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 4 to 250  |  Coverage: 96% PNP_UDP_1 Range: 3 to 252  |  Coverage: 97% 1 Range: 1 to 255  |  Coverage: 99% 1
Number of amino acids : 255
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PNP_UDP_1PF010484-250
Mtb Structural Proteome models
Model Number1
Model nameRv0091
Template1ZOS    APDBCREDO
Template coverage1_229
Template Identity(%)33.2
Model coverage(%)97.6
Normalized DOPE score-0.705

Structure Models from Chopin
Model Number1
Profilec.56.2.1 - 3.40.50.1580
Click for model details
zscore21.23
Residue begin1
Residue end255
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0091Gene nameConfidence Score
Rv0535pnp0.982
Rv1392metK0.951
Rv1392metK0.951
Rv1392metK0.951
Rv2601speE0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
methylthioadenosinePubChem0.975297.333
5'-deoxy-5'-methylthioadenosinePubChem0.975297.333
S-adenosylhomocysteinePubChem0.971384.411
adeninePubChem0.878135.127
MT-DADMe-ImmAPubChem0.877293.388
formycinPubChem0.849267.241
FMCPubChem0.795267.241
DB02158PubChem0.794297.377
5'-methylthiotubercidinPubChem0.788296.345
glycerolPubChem0.77292.0938
AI-2PubChem0.771192.94
Azetidine based compound, 44PubChem0.766263.362
DB07463PubChem0.765335.468
Azetidine based compound, 43PubChem0.755329.849
4-hydroxy-5-methyl-3(2H)-furanonePubChem0.735114.099