SInCRe - Rv0535

Tuberculist information

Gene name	pnp
Protein function	Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	626.457
Molecular mass(da)	27963.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 264

	  		  	1    MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHH   60
			  	61   QYSAHAVPYRANMWALRALGVRRVFGPCAVGSLDPELEPGAVVVPDQLVDRTSGRADTYF  120
			  	121  DFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPRFSTRAESQWFAAAGCNLVNM  180
			  	181  TGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAADVFAAFGENIELLKRLVRAAID  240
			  	241  RVADERTCTHCQHHAGVPLPFELP

Known structures in the PDB

No Known structures

Number of amino acids : 264

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
PNP_UDP_1	PF01048	7-243

Mtb Structural Proteome models

Model Number	1
Model name	Rv0535
Template	2A8Y APDB CREDO
Template coverage	5_262
Template Identity(%)	45.1
Model coverage(%)	92.5
Normalized DOPE score	-0.795

Structure Models from Chopin

Model Number	1
Profile	c.56.2.1 - 3.40.50.1580 Click for model details
zscore	23.3
Residue begin	1
Residue end	264

Binding pockets

STRING

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Protein interacting with Rv0535	Gene name	Confidence Score
Rv0091	mtn	0.982
Rv2601	speE	0.911

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
5'-deoxy-5'-methylthioadenosinePubChem	0.992	297.333
methylthioadenosinePubChem	0.991	297.333
adeninePubChem	0.901	135.127
phosphatePubChem	0.893	96.9872
5'-methylthiotubercidinPubChem	0.828	296.345
MT-DADMe-ImmAPubChem	0.817	293.388
hydron diphosphatePubChem	0.78	391.981
FCE 22176PubChem	0.78	362.503
hydron sulfatePubChem	0.78	196.157
sulfatePubChem	0.78	96.0626