Rv3048c

Tuberculist information
Gene namenrdF2
Protein functionRibonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein)
Functional category(tuberculist)information pathways
Gene location(kb)3408.4
Molecular mass(da)36959.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 324
	  		  	1    VTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQL   60
			  	61   TMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCST  120
			  	121  AEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSR  180
			  	181  AKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAELKDYTYELLFELYDNEVE  240
			  	241  YTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHD  300
			  	301  FFSGSGSSYVIGKAVVTEDDDWDF

Known structures in the PDB
PDB ID1UZR
Total residue count888
Number of chains3
MethodX-RAY
Resolution2.2
1 33 65 97 129 161 193 225 257 289 321 Range: 7 to 286  |  Coverage: 86% Ribonuc_red_sm Range: 10 to 291  |  Coverage: 86% 1 Range: 10 to 291  |  Coverage: 86% 2 Range: 1 to 314  |  Coverage: 96% 1
Number of amino acids : 324
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribonuc_red_smPF002687-286
Mtb Structural Proteome models
Model Number1
Model nameRv3048c_1uzr_A
Template1UZR    APDBCREDO
Template coverage10_291
Template Identity(%)100.0
Model coverage(%)86.7
Normalized DOPE score-2.858

Model Number2
Model nameRv3048c
Template1UZR    APDBCREDO
Template coverage10_291
Template Identity(%)99.6
Model coverage(%)86.7
Normalized DOPE score-2.612

Structure Models from Chopin
Model Number1
Profilea.25.1.2 - 1.10.620.20
Click for model details
zscore16.44
Residue begin1
Residue end314
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3048cGene nameConfidence Score
Rv3051cnrdE0.999
Rv3051cnrdE0.999
Rv3051cnrdE0.999
Rv3052cnrdI0.996
Rv2764cthyA0.979
Rv0570nrdZ0.966
Rv0570nrdZ0.966
Rv0570nrdZ0.966
Rv0733adk0.966
Rv2445cndkA0.95
Rv1389gmk0.943
Rv1617pykA0.943
Rv1617pykA0.943
Rv3053cnrdH0.915
Rv1981cnrdF10.906
Rv1341Rv13410.905
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Fe(III)PubChem0.97255.845
glycerolPubChem0.95492.0938
adenosine monophosphatePubChem0.9347.221
dUDPPubChem0.9388.162
cytidine diphosphatePubChem0.9403.176
guanosine diphosphatePubChem0.9443.201
dADPPubChem0.9411.202
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
YYYPubChem0.9387.177
uridine diphosphatePubChem0.9404.161
adenosine diphosphatePubChem0.9427.201
dGDPPubChem0.9427.201
adenosine triphosphatePubChem0.9507.181
deoxyuridine triphosphatePubChem0.9468.142
citratePubChem0.9192.124
deoxyadenosine triphosphatePubChem0.9491.182
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
deoxycytidine triphosphatePubChem0.9467.157