Rv1981c

Tuberculist information
Gene namenrdF1
Protein functionRibonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)
Functional category(tuberculist)information pathways
Gene location(kb)2224.22
Molecular mass(da)36589.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 322
	  		  	1    MTGKLVERVHAINWNRLLDAKDLQVWERLTGNFWLPEKIPLSNDLASWQTLSSTEQQTTI   60
			  	61   RVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVLTNMAFMESVHAKSYSSIFSTLCSTKQ  120
			  	121  IDDAFDWSEQNPYLQRKAQIIVDYYRGDDALKRKASSVMLESFLFYSGFYLPMYWSSRGK  180
			  	181  LTNTADLIRLIIRDEAVHGYYIGYKCQRGLADLTDAERADHREYTCELLHTLYANEIDYA  240
			  	241  HDLYDELGWTDDVLPYMRYNANKALANLGYQPAFDRDTCQVNPAVRAALDPGAGENHDFF  300
			  	301  SGSGSSYVMGTHQPTTDTDWDF

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 5 to 284  |  Coverage: 86% Ribonuc_red_sm Range: 8 to 289  |  Coverage: 87% 1 Range: 1 to 312  |  Coverage: 96% 1
Number of amino acids : 322
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribonuc_red_smPF002685-284
Mtb Structural Proteome models
Model Number1
Model nameRv1981c
Template1UZR    APDBCREDO
Template coverage10_291
Template Identity(%)71.3
Model coverage(%)87.3
Normalized DOPE score-1.979

Structure Models from Chopin
Model Number1
Profilea.25.1.2 - 1.10.620.20
Click for model details
zscore15.99
Residue begin1
Residue end312
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1981cGene nameConfidence Score
Rv3051cnrdE0.999
Rv3051cnrdE0.999
Rv3051cnrdE0.999
Rv3052cnrdI0.998
Rv2764cthyA0.974
Rv3053cnrdH0.972
Rv0733adk0.953
Rv2445cndkA0.937
Rv1617pykA0.936
Rv1617pykA0.936
Rv1389gmk0.925
Rv0570nrdZ0.924
Rv0570nrdZ0.924
Rv0570nrdZ0.924
Rv3048cnrdF20.906
Rv1341Rv13410.904
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cytidine diphosphatePubChem0.9403.176
dGDPPubChem0.9427.201
guanosine diphosphatePubChem0.9443.201
adenosine diphosphatePubChem0.9427.201
dADPPubChem0.9411.202
dUDPPubChem0.9388.162
Fe(III)PubChem0.76955.845