Rv3053c

Tuberculist information
Gene namenrdH
Protein functionProbable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH
Functional category(tuberculist)information pathways
Gene location(kb)3414.72
Molecular mass(da)8418.67
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 79
	  		  	1    MTVTVYTKPACVQCSATSKALDKQGIAYQKVDISLDSEARDYVMALGYLQAPVVVAGNDH   60
			  	61   WSGFRPDRIKALAGAALTA

Known structures in the PDB
PDB ID4F2I
Total residue count84
Number of chains1
MethodX-RAY
Resolution1.67
PDB ID4HS1
Total residue count85
Number of chains1
MethodX-RAY
Resolution0.87
PDB ID4K8M
Total residue count84
Number of chains1
MethodX-RAY
Resolution0.87
1 8 15 22 29 36 43 50 57 64 71 Range: 3 to 61  |  Coverage: 73% Glutaredoxin Range: 1 to 72  |  Coverage: 89% 1 Range: 1 to 79  |  Coverage: 98% 1
Number of amino acids : 79
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GlutaredoxinPF004623-61
Mtb Structural Proteome models
Model Number1
Model nameRv3053c
Template1R7H    APDBCREDO
Template coverage1_72
Template Identity(%)73.6
Model coverage(%)88.8
Normalized DOPE score0.306

Structure Models from Chopin
Model Number1
Profilec.47.1.12 - 3.40.30.10
Click for model details
zscore14.79
Residue begin1
Residue end79
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3053cGene nameConfidence Score
Rv3052cnrdI0.999
Rv3051cnrdE0.997
Rv3051cnrdE0.997
Rv3051cnrdE0.997
Rv1981cnrdF10.972
Rv3048cnrdF20.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions