SInCRe - Rv0570

Tuberculist information

Gene name	nrdZ
Protein function	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)
Functional category(tuberculist)	information pathways
Gene location(kb)	661.295
Molecular mass(da)	74489
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 692

	  		  	1    VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP   60
			  	61   VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER  120
			  	121  YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL  180
			  	181  MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG  240
			  	241  GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL  300
			  	301  SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN  360
			  	361  RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL  420
			  	421  DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ  480
			  	481  AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI  540
			  	541  AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA  600
			  	601  EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR  660
			  	661  EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF

Known structures in the PDB

No Known structures

Number of amino acids : 692

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
ATP-cone	PF03477	7-93
Ribonuc_red_lgN	PF00317	107-188
Ribonuc_red_lgC	PF02867	190-508
Ribonuc_red_lgC	PF02867	505-656

Mtb Structural Proteome models

Model Number	1
Model name	Rv0570
Template	1XJJ APDB CREDO
Template coverage	2_632
Template Identity(%)	39.9
Model coverage(%)	81.4
Normalized DOPE score	-0.514

Structure Models from Chopin

Model Number	1
Profile	c.7.1.4 Click for model details
zscore	44.68
Residue begin	1
Residue end	319

Model Number	2
Profile	c.7.1.4 Click for model details
zscore	44.68
Residue begin	190
Residue end	508

Model Number	3
Profile	c.7.1.4 Click for model details
zscore	44.68
Residue begin	505
Residue end	823

Model Number	4
Profile	a.98.1.1, c.7.1.2 Click for model details
zscore	41.56
Residue begin	1
Residue end	319

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0570	Gene name	Confidence Score
Rv2445c	ndkA	0.967
Rv3048c	nrdF2	0.966
Rv1617	pykA	0.964
Rv1617	pykA	0.964
Rv0733	adk	0.955
Rv1341	Rv1341	0.935
Rv3247c	tmk	0.93
Rv2718c	nrdR	0.926
Rv1389	gmk	0.925
Rv1981c	nrdF1	0.924
Rv2783c	gpsI	0.914
Rv2783c	gpsI	0.914
Rv2783c	gpsI	0.914
Rv2783c	gpsI	0.914
Rv2783c	gpsI	0.914

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
cytidine diphosphatePubChem	0.969	403.176
guanosine diphosphatePubChem	0.969	443.201
adenosine diphosphatePubChem	0.969	427.201
dGDPPubChem	0.906	427.201
dUDPPubChem	0.901	388.162
dADPPubChem	0.9	411.202
glycerolPubChem	0.724	92.0938
magnesiumPubChem	0.724	24.305
deoxyadenosine triphosphatePubChem	0.707	491.182
thymidine triphosphatePubChem	0.701	482.168
uridine diphosphatePubChem	0.7	404.161
deoxyguanosine triphosphatePubChem	0.7	507.181