Rv2782c

Tuberculist information
Gene namepepR
Protein functionProbable zinc protease PepR
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3089.04
Molecular mass(da)47072.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 438
	  		  	1    MPRRSPADPAAALAPRRTTLPGGLRVVTEFLPAVHSASVGVWVGVGSRDEGATVAGAAHF   60
			  	61   LEHLLFKSTPTRSAVDIAQAMDAVGGELNAFTAKEHTCYYAHVLGSDLPLAVDLVADVVL  120
			  	121  NGRCAADDVEVERDVVLEEIAMRDDDPEDALADMFLAALFGDHPVGRPVIGSAQSVSVMT  180
			  	181  RAQLQSFHLRRYTPERMVVAAAGNVDHDGLVALVREHFGSRLVRGRRPVAPRKGTGRVNG  240
			  	241  SPRLTLVSRDAEQTHVSLGIRTPGRGWEHRWALSVLHTALGGGLSSRLFQEVRETRGLAY  300
			  	301  SVYSALDLFADSGALSVYAACLPERFADVMRVTADVLESVARDGITEAECGIAKGSLRGG  360
			  	361  LVLGLEDSSSRMSRLGRSELNYGKHRSIEHTLRQIEQVTVEEVNAVARHLLSRRYGAAVL  420
			  	421  GPHGSKRSLPQQLRAMVG

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 25 to 173  |  Coverage: 33% Peptidase_M16 Range: 179 to 357  |  Coverage: 40% Peptidase_M16_C Range: 13 to 429  |  Coverage: 94% 1 Range: 25 to 173  |  Coverage: 33% 1 Range: 1 to 431  |  Coverage: 98% 2
Number of amino acids : 438
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M16PF0067525-173
Peptidase_M16_CPF05193179-357
Mtb Structural Proteome models
Model Number1
Model nameRv2782c
Template1HR6    BPDBCREDO
Template coverage24_453
Template Identity(%)27.8
Model coverage(%)95.0
Normalized DOPE score-0.34

Structure Models from Chopin
Model Number1
Profile3.30.830.10
Click for model details
zscore17.19
Residue begin25
Residue end173
Model Number2
Profile3.30.830.10
Click for model details
zscore10.55
Residue begin1
Residue end431
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2782cGene nameConfidence Score
Rv2783cgpsI0.981
Rv2783cgpsI0.981
Rv2783cgpsI0.981
Rv2783cgpsI0.981
Rv2783cgpsI0.981
Rv3846sodA0.924
Rv3846sodA0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.83465.409