Rv1412

Tuberculist information
Gene nameribC
Protein functionProbable riboflavin synthase alpha chain RibC (RibE)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1588.57
Molecular mass(da)21320.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 201
	  		  	1    MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFT   60
			  	61   ADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEV  120
			  	121  VRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSLIPTTRELTTLGSAAVGT  180
			  	181  RVNLEVDVVAKYVERLMRSAG

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 3 to 87  |  Coverage: 41% Lum_binding Range: 100 to 187  |  Coverage: 43% Lum_binding Range: 1 to 199  |  Coverage: 98% 1 Range: 98 to 187  |  Coverage: 44% 1
Number of amino acids : 201
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Lum_bindingPF006773-87
Lum_bindingPF00677100-187
Mtb Structural Proteome models
Model Number1
Model nameRv1412
Template1KZL    APDBCREDO
Template coverage1_197
Template Identity(%)38.6
Model coverage(%)98.5
Normalized DOPE score-0.433

Structure Models from Chopin
Model Number1
Profileb.43.4.3 - 2.40.30.20
Click for model details
zscore23.37
Residue begin98
Residue end187
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1412Gene nameConfidence Score
Rv1416ribH0.999
Rv1415ribA20.996
Rv1415ribA20.996
Rv1409ribG0.985
Rv1409ribG0.985
Rv1940ribA10.969
Rv1940ribA10.969
Rv2786cribF0.934
Rv2786cribF0.934
Rv2533cnusB0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
riboflavinPubChem0.987376.364
6,7-dimethyl-8-ribityllumazinePubChem0.963326.305
phosphatePubChem0.91296.9872
adenosine triphosphatePubChem0.9507.181
6,7-dimethyl-8-(2,3,4,5-tetrahydroxypentyl)pteridine-2,4-dionePubChem0.9326.305
FAD semiquinonePubChem0.9376.364
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedionePubChem0.9276.247
3,4-dihydroxy-2-butanone 4-phosphatePubChem0.9184.084
H(+)PubChem0.92.01588
flavin mononucleotidePubChem0.9456.344
5-amino-2,6-dioxo-4-ribitylaminopyrimidinePubChem0.9276.247
hydroxyl radicalsPubChem0.917.0073
adenosine diphosphatePubChem0.9427.201