Tuberculist information
Gene nameribA1
Protein functionProbable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2192.61
Molecular mass(da)36869.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 353
	  		  	1    MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVRHTSGYLRVAL   60
			  	61   PGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTIAALASATSVAADFQRPGH  120
			  	121  VVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIVSPDNPVQMAHHAESVEFAVE  180
			  	181  HGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVG  240
			  	241  AGVPVPLHVHIECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLF  300
			  	301  ARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLAAAG
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DHBP_synthasePF009268-195
GTP_cyclohydro2PF00925202-334
Mtb Structural Proteome models
Model Number1
Model nameRv1940
Template1K4I    APDBCREDO
Template coverage19_224
Template Identity(%)41.5
Model coverage(%)53.0
Normalized DOPE score-0.861

Model Number2
Model nameRv1940.4
Template2BZ1    APDBCREDO
Template coverage1_171
Template Identity(%)31.6
Model coverage(%)42.8
Normalized DOPE score-0.145

Structure Models from Chopin
Model Number1
Profiled.115.1.2 - 3.90.870.10
Click for model details
zscore42.55
Residue begin8
Residue end195
Model Number2
Profilec.144.1.1
Click for model details
zscore35.19
Residue begin202
Residue end334
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1940Gene nameConfidence Score
Rv1416ribH0.998
Rv1409ribG0.997
Rv1409ribG0.997
Rv1412ribC0.969
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv1940.421uwh_BAX_B_1723PDBCREDO0.6940.0860.6340.001
Rv1940.421uwh_BAX_A_1723PDBCREDO0.6930.0860.6340.001
Rv1940.421uwj_BAX_B_1723PDBCREDO0.6510.1230.6330.001
Rv1940.423spk_TPV_B_100PDBCREDO0.6320.1430.6320.001
Rv1940.424asd_BAX_A_1500PDBCREDO0.6480.1260.6290.001
Rv1940.421uwj_BAX_A_1723PDBCREDO0.6630.1120.6260.001
Rv1940.421t46_STI_A_3PDBCREDO0.7330.0580.6030.002
Rv1940.422hyy_STI_B_600PDBCREDO0.6350.1400.5980.002
Rv1940.423d91_REM_A_350PDBCREDO0.6150.1610.5970.002
Rv1940.423so9_017_A_100PDBCREDO0.6530.1210.5970.002
Rv1940.423mss_STI_B_1PDBCREDO0.6130.1640.5950.002
Rv1940.422hyy_STI_C_600PDBCREDO0.6120.1650.5940.002
Rv1940.422pl0_STI_A_200PDBCREDO0.6300.1440.5940.002
Rv1940.423mss_STI_D_1PDBCREDO0.6100.1670.5930.002
Rv1940.423pyy_STI_B_4PDBCREDO0.6100.1670.5930.002
Rv1940.422hyy_STI_D_600PDBCREDO0.6090.1680.5920.002
Rv1940.421n49_RIT_D_401PDBCREDO0.6090.1690.5910.002
Rv1940.421z2b_VLB_C_800PDBCREDO0.6270.1480.5910.002
Rv1940.423pyy_STI_A_3PDBCREDO0.6080.1690.5910.002
Rv1940.423mss_STI_A_1PDBCREDO0.6080.1700.5900.003
Rv1940.423oez_STI_A_601PDBCREDO0.6080.1700.5900.003
Rv1940.423d91_REM_B_350PDBCREDO0.6070.1710.5900.003
Rv1940.423ms9_STI_A_1PDBCREDO0.6070.1710.5890.003
Rv1940.422hyy_STI_A_600PDBCREDO0.6060.1720.5890.003
Rv1940.423k5v_STI_B_2PDBCREDO0.6060.1720.5890.003
Rv1940.423ms9_STI_B_1PDBCREDO0.6060.1720.5890.003
Rv1940.421iep_STI_A_201PDBCREDO0.6060.1720.5880.003
Rv1940.423mss_STI_C_1PDBCREDO0.6050.1730.5880.003
Rv1940.423heg_BAX_A_1PDBCREDO0.6230.1530.5870.003
Rv1940.421iep_STI_B_202PDBCREDO0.6040.1740.5870.003
Rv1940.422w8y_486_A_1000PDBCREDO0.6040.1750.5860.003
Rv1940.423h52_486_D_2PDBCREDO0.6400.1350.5850.003
Rv1940.423gvu_STI_A_1001PDBCREDO0.6010.1780.5840.003
Rv1940.421sa1_POD_B_700PDBCREDO0.6010.1780.5830.003
Rv1940.423h52_486_B_1PDBCREDO0.6160.1600.5810.003
Rv1940.422oiq_STI_A_1001PDBCREDO0.6160.1610.5800.003
Rv1940.422qxs_RAL_A_600PDBCREDO0.6680.1080.5800.003
Rv1940.422qxs_RAL_B_600PDBCREDO0.6670.1080.5790.003
Rv1940.422jfa_RAL_A_600PDBCREDO0.6730.1030.5780.003
Rv1940.423gcs_BAX_A_401PDBCREDO0.5950.1850.5780.003
Rv1940.422nni_MTK_A_501PDBCREDO0.5770.2070.5770.003
Rv1940.422jfa_RAL_B_600PDBCREDO0.6500.1240.5770.003
Rv1940.423tkd_CYZ_B_267PDBCREDO0.6310.1440.5770.003
Rv1940.421xkk_FMM_A_91PDBCREDO0.7370.0550.5760.003
Rv1940.421err_RAL_A_600PDBCREDO0.6460.1290.5720.003
Rv1940.421sa1_POD_D_701PDBCREDO0.6070.1700.5720.003
Rv1940.421err_RAL_B_600PDBCREDO0.6450.1300.5720.003
Rv1940.423bbt_FMM_D_91PDBCREDO0.7830.0310.5710.004
Rv1940.423tne_RIT_A_401PDBCREDO0.6640.1110.5700.004
Rv1940.422y6o_1N1_A_1892PDBCREDO0.6820.0950.5680.004
Rv1940.421opj_STI_B_4PDBCREDO0.6350.1400.5670.004
Rv1940.421opj_STI_A_3PDBCREDO0.6330.1420.5650.004
Rv1940.421lhv_NOG_A_301PDBCREDO0.6770.1000.5640.004
Rv1940.423k5v_STI_A_2PDBCREDO0.6130.1630.5630.004
Rv1940.423cs9_NIL_A_600PDBCREDO0.6300.1440.5630.004
Rv1940.421n49_RIT_B_301PDBCREDO0.6300.1450.5620.004
Rv1940.423oez_STI_B_601PDBCREDO0.6540.1200.5620.004
Rv1940.423q70_RIT_A_2001PDBCREDO0.5970.1830.5620.004
Rv1940.423frq_ERY_A_195PDBCREDO0.5590.2310.5590.004
Rv1940.422oax_SNL_D_4001PDBCREDO0.5930.1880.5590.004
Rv1940.422oax_SNL_E_5001PDBCREDO0.5930.1880.5590.004
Rv1940.422oax_SNL_A_1001PDBCREDO0.5890.1920.5550.005
Rv1940.432y7w_SAL_A_1300PDBCREDO0.5880.1930.5550.005
Rv1940.423b0w_DGX_A_1PDBCREDO0.5710.2150.5550.005
Rv1940.423b0w_DGX_B_1PDBCREDO0.6040.1750.5540.005
Rv1940.422oax_SNL_F_6001PDBCREDO0.5880.1940.5540.005
Rv1940.423h52_486_A_3PDBCREDO0.6060.1720.5540.005
Rv1940.493ubo_ADN_B_353PDBCREDO0.5750.2100.5500.005
Rv1940.421qkn_RAL_A_600PDBCREDO0.6810.0960.5490.005
Rv1940.432y7p_SAL_A_1000PDBCREDO0.5800.2040.5480.005
Rv1940.423spk_TPV_A_100PDBCREDO0.7250.0630.5470.005
Rv1940.491bx4_ADN_A_350PDBCREDO0.5470.2480.5470.005
Rv1940.423rgf_BAX_A_465PDBCREDO0.5780.2060.5460.005
Rv1940.413pww_ROC_A_1001PDBCREDO0.5600.2310.5450.005
Rv1940.423cs9_NIL_B_600PDBCREDO0.6270.1480.5450.005
Rv1940.423gp0_NIL_A_1PDBCREDO0.6780.0990.5440.006
Rv1940.421y0x_T44_X_500PDBCREDO0.5940.1860.5430.006
Rv1940.493ubo_ADN_A_353PDBCREDO0.5660.2220.5420.006
Rv1940.421t7j_478_A_200PDBCREDO0.5920.1890.5410.006
Rv1940.423frq_ERY_B_195PDBCREDO0.6290.1460.5410.006
Rv1940.423cs9_NIL_D_600PDBCREDO0.6550.1200.5390.006
Rv1940.422fum_MIX_D_3539PDBCREDO0.7390.0540.5390.006
Rv1940.423sm2_478_A_126PDBCREDO0.7250.0630.5380.006
Rv1940.423mnp_DEX_A_784PDBCREDO0.6060.1720.5370.006
Rv1940.423tkd_CYZ_A_266PDBCREDO0.6250.1510.5370.006
Rv1940.423uvv_T3_A_501PDBCREDO0.6450.1300.5370.006
Rv1940.413prs_RIT_A_1001PDBCREDO0.6080.1690.5360.006
Rv1940.421xzx_T3_X_500PDBCREDO0.6430.1320.5350.006
Rv1940.423v5w_8PR_A_701PDBCREDO0.6640.1110.5350.006
Rv1940.423cs9_NIL_C_600PDBCREDO0.6500.1250.5350.006
Rv1940.421uob_PNN_A_1311PDBCREDO0.5660.2220.5330.007
Rv1940.423mno_DEX_A_784PDBCREDO0.6000.1790.5320.007
Rv1940.422hw2_RFP_A_1200PDBCREDO0.6190.1570.5320.007
Rv1940.423hec_STI_A_1PDBCREDO0.6180.1580.5310.007
Rv1940.423tne_RIT_B_401PDBCREDO0.6180.1590.5310.007
Rv1940.423el9_DR7_A_100PDBCREDO0.6270.1480.5300.007
Rv1940.422ab2_SNL_B_503PDBCREDO0.6170.1600.5300.007
Rv1940.422ab2_SNL_A_502PDBCREDO0.6160.1600.5290.007
Rv1940.421a28_STR_B_2PDBCREDO0.6350.1400.5290.007
Rv1940.423ut5_LOC_B_502PDBCREDO0.5770.2070.5280.007
Rv1940.423e22_LOC_D_700PDBCREDO0.6120.1650.5260.007
Rv1940.432y7k_SAL_A_1302PDBCREDO0.5880.1930.5260.007
Rv1940.422oax_SNL_C_3001PDBCREDO0.6110.1660.5250.007
Rv1940.423ut5_LOC_D_502PDBCREDO0.6110.1660.5250.007
Rv1940.423vhu_SNL_A_1001PDBCREDO0.6100.1670.5240.008
Rv1940.423e22_LOC_B_700PDBCREDO0.6100.1680.5240.008
Rv1940.423el0_1UN_A_201PDBCREDO0.5710.2160.5240.008
Rv1940.423gws_T3_X_500PDBCREDO0.6480.1260.5230.008
Rv1940.423ufn_ROC_A_401PDBCREDO0.6520.1230.5230.008
Rv1940.422oax_SNL_B_2001PDBCREDO0.6080.1700.5220.008
Rv1940.421c6y_MK1_B_524PDBCREDO0.6160.1600.5210.008
Rv1940.421bsx_T3_A_1PDBCREDO0.6460.1280.5210.008
Rv1940.421bsx_T3_B_2PDBCREDO0.6460.1280.5210.008
Rv1940.421fm6_BRL_X_504PDBCREDO0.6240.1510.5200.008
Rv1940.421mx1_THA_C_3PDBCREDO0.7630.0410.5190.008
Rv1940.421jg2_ADN_A_500PDBCREDO0.7360.0560.5180.008
Rv1940.421p93_DEX_C_3999PDBCREDO0.6420.1320.5170.008
Rv1940.411c6z_ROC_B_505PDBCREDO0.5730.2130.5170.008
Rv1940.422aa6_STR_A_401PDBCREDO0.6630.1120.5170.008
Rv1940.423oht_1N1_B_1000PDBCREDO0.7580.0430.5160.009
Rv1940.411t46_STI_A_3PDBCREDO0.5290.2740.5150.009
Rv1940.493g0f_B49_A_9001PDBCREDO0.5630.2260.5150.009
Rv1940.422x9g_LYA_A_1270PDBCREDO0.6180.1590.5140.009
Rv1940.421m2z_DEX_A_301PDBCREDO0.6370.1370.5140.009
Rv1940.423mne_DEX_A_784PDBCREDO0.6370.1370.5140.009
Rv1940.423kk6_CEL_B_1701PDBCREDO0.5910.1900.5130.009
Rv1940.422aa6_STR_B_402PDBCREDO0.6570.1170.5130.009
Rv1940.423ogp_017_A_200PDBCREDO0.5440.2520.5130.009
Rv1940.413q70_RIT_A_2001PDBCREDO0.6780.0980.5130.009
Rv1940.421m2z_DEX_D_401PDBCREDO0.6350.1400.5120.009
Rv1940.492pkm_ADN_A_501PDBCREDO0.5340.2660.5110.009
Rv1940.421p93_DEX_D_4999PDBCREDO0.6340.1410.5110.009
Rv1940.494e3a_ADN_A_500PDBCREDO0.5810.2030.5110.009
Rv1940.4313gs_SAS_A_211PDBCREDO0.5420.2550.5110.009
Rv1940.4313gs_SAS_B_211PDBCREDO0.5420.2550.5110.009
Rv1940.422aax_PDN_B_503PDBCREDO0.6550.1200.5110.009
Rv1940.423pww_ROC_A_1001PDBCREDO0.6200.1560.5110.009
Rv1940.493g0f_B49_B_9001PDBCREDO0.5580.2330.5100.009
Rv1940.423gn8_DEX_A_247PDBCREDO0.6320.1420.5100.009
Rv1940.421s9p_DES_A_459PDBCREDO0.7490.0490.5090.009
Rv1940.422aax_PDN_A_502PDBCREDO0.6530.1210.5090.009
Rv1940.423lzv_017_A_200PDBCREDO0.5540.2380.5090.010
Rv1940.423gn8_DEX_B_247PDBCREDO0.6310.1440.5090.010
Rv1940.423ekq_ROC_A_100PDBCREDO0.5850.1970.5080.010
Rv1940.422fxd_DR7_A_102PDBCREDO0.6010.1780.5080.010
Rv1940.421nhz_486_A_800PDBCREDO0.6730.1030.5080.010
Rv1940.422r5q_1UN_D_900PDBCREDO0.5070.3080.5070.010
Rv1940.422r5q_1UN_B_900PDBCREDO0.5060.3080.5060.010
Rv1940.423oct_1N1_A_663PDBCREDO0.7180.0680.5060.010
Rv1940.421zgy_BRL_A_503PDBCREDO0.6700.1060.5060.010
Rv1940.423vn2_TLS_A_501PDBCREDO0.5700.2170.5060.010
Rv1940.422h79_T3_A_1PDBCREDO0.6470.1270.5050.010
Rv1940.433hgx_SAL_A_102PDBCREDO0.5650.2240.5050.010
Rv1940.413tne_RIT_B_401PDBCREDO0.7320.0580.5040.010
Rv1940.422gqg_1N1_B_502PDBCREDO0.6450.1290.5030.010
Rv1940.422h42_VIA_A_901PDBCREDO0.6880.0900.5020.011
Rv1940.423h0a_9RA_A_500PDBCREDO0.6880.0900.5020.011
Rv1940.421hwk_117_B_1PDBCREDO0.5170.2930.5020.011
Rv1940.423ogp_017_B_200PDBCREDO0.5170.2930.5020.011
Rv1940.433ret_SAL_A_201PDBCREDO0.5610.2280.5020.011
Rv1940.423bjw_SVR_E_503PDBCREDO0.5930.1880.5010.011
Rv1940.422fum_MIX_A_539PDBCREDO0.7630.0410.5010.011
Rv1940.412v0z_C41_O_1327PDBCREDO0.5010.3170.5010.011
Rv1940.422xkw_P1B_A_1478PDBCREDO0.6570.1180.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ribulose 5-phosphatePubChem0.949230.11
3,4-dihydroxy-2-butanone 4-phosphatePubChem0.943184.084
ribulose-5-phosphatePubChem0.922230.11
guanosine triphosphatePubChem0.905523.18
C01304PubChem0.9353.226