Rv2725c

Tuberculist information
Gene namehflX
Protein functionProbable GTP-binding protein HflX
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3037.43
Molecular mass(da)53327.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 495
	  		  	1    MPANSDARPAATCHHRVLAMTYPDPPQTGLSDFTPSLGELALEDRSALRRVAGLSTELAD   60
			  	61   VSEVEYRQLRLERVVLVGVWTEGSAADNRASLAELAALAETAGSQVLEGLIQRRDKPDPS  120
			  	121  TYIGSGKAAELREVIVATGADTVICDGELSPAQLTALEKAVQVKVIDRTALILDIFAQHA  180
			  	181  TSREGKAQVSLAQMEYMLPRLRGWGESMSRQAGGRAGGSGGGVGLRGPGETKIETDRRRI  240
			  	241  RERMAKLRRDIRAMKQVRDTQRSRRRHSDVPSIAIVGYTNAGKSSLLNALTGAGVLVQDA  300
			  	301  LFATLEPTTRRAEFGDGRPVVLTDTVGFVRHLPTQLVEAFRSTLEEVVHADLLVHVVDGS  360
			  	361  DGHPLAQIDAVRQVISEVIADHDGDPPPELLVVNKVDVASDLMLAKLRHGLPGAVFVSAR  420
			  	421  TGDGIDALRRRMAELVVPADTAVDVVIPYDRGDLVARVHADGRIQQAEHKPEGTRIKARV  480
			  	481  PEALAATLREFAPRA

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 85 to 177  |  Coverage: 18% GTP-bdg_N Range: 272 to 395  |  Coverage: 24% MMR_HSR1 Range: 205 to 494  |  Coverage: 58% 1 Range: 272 to 395  |  Coverage: 24% 1
Number of amino acids : 495
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP-bdg_NPF1316785-177
MMR_HSR1PF01926272-395
Mtb Structural Proteome models
Model Number1
Model nameRv2725c
Template1UDX    APDBCREDO
Template coverage100_386
Template Identity(%)23.3
Model coverage(%)58.4
Normalized DOPE score0.683

Structure Models from Chopin
Model Number1
Profilec.37.1.21 - 3.40.50.300
Click for model details
zscore4.67
Residue begin272
Residue end395
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2725cGene nameConfidence Score
Rv2727cmiaA0.992
Rv3011cgatA0.967
Rv2388chemN0.959
Rv2388chemN0.959
Rv1098cfum0.932
Rv1098cfum0.932
Rv1710scpB0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions