Rv1569

Tuberculist information
Gene namebioF1
Protein functionProbable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1776.7
Molecular mass(da)40027.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVI   60
			  	61   DGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGL  120
			  	121  SGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFS  180
			  	181  ADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKA  240
			  	241  LGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHA  300
			  	301  GELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLT  360
			  	361  ARASLNAGELELARRVLTDVLAVARR

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 40 to 377  |  Coverage: 87% Aminotran_1_2 Range: 4 to 377  |  Coverage: 96% 1 Range: 1 to 386  |  Coverage: 99% 1
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_1_2PF0015540-377
Mtb Structural Proteome models
Model Number1
Model nameRv1569
Template1BS0    APDBCREDO
Template coverage2_380
Template Identity(%)32.6
Model coverage(%)96.6
Normalized DOPE score0.109

Structure Models from Chopin
Model Number1
Profilec.67.1.4
Click for model details
zscore20.08
Residue begin1
Residue end386
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1569Gene nameConfidence Score
Rv1568bioA0.999
Rv1570bioD0.995
Rv1589bioB0.984
Rv1589bioB0.984
Rv1571Rv15710.975
Rv2753cdapA0.912
Rv1567cRv1567c0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
7-keto-8-aminopelargonic acidPubChem0.977187.236
pimeloyl-CoAPubChem0.977909.687
L-alaninePubChem0.9789.0932
8-amino-7-oxononanoic acidPubChem0.963187.236
7,8-diaminopelargonic acidPubChem0.927188.267
carbon dioxidePubChem0.92544.0095
pyridoxal phosphatePubChem0.909247.142
coenzyme APubChem0.906767.534
H(+)PubChem0.9032.01588
deuteriumPubChem0.9022.01588
S-adenosyl-L-methioninePubChem0.9399.445
7,8-diaminononanoic acidPubChem0.9188.267
Co-APubChem0.9767.534
S-adenosyl-methioninePubChem0.9398.437
S-adenosyl-4-methylthio-2-oxobutanoatePubChem0.9398.414
protiumPubChem0.92.01576