Rv0415

Tuberculist information
Gene namethiO
Protein functionPossible thiamine biosynthesis oxidoreductase ThiO
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)501.148
Molecular mass(da)36534.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 340
	  		  	1    MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGASWVAGGMLAPHSEGWPG   60
			  	61   EERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRADVADLRTVADWLSAQGHP  120
			  	121  VIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALCRDCERLGVRWSSQVSSLSDV  180
			  	181  DAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGCMPLPQRVIRARVRGRQVYLVPR  240
			  	241  SDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLPALGEYELAECEAGLRPMTPDNLPL  300
			  	301  VQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELVSVGAAS

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 9 to 333  |  Coverage: 95% DAO Range: 6 to 336  |  Coverage: 97% 1 Range: 8 to 340  |  Coverage: 97% 1 Range: 202 to 296  |  Coverage: 27% 2 Range: 1 to 100  |  Coverage: 29% 3
Number of amino acids : 340
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DAOPF012669-333
Mtb Structural Proteome models
Model Number1
Model nameRv0415
Template1RYI    APDBCREDO
Template coverage3_349
Template Identity(%)26.6
Model coverage(%)97.1
Normalized DOPE score-0.158

Structure Models from Chopin
Model Number1
Profile3.30.9.10, 3.40.50.720
Click for model details
zscore22.34
Residue begin8
Residue end340
Model Number2
Profiled.16.1.3
Click for model details
zscore9.12
Residue begin202
Residue end296
Model Number3
Profilec.5.1.1
Click for model details
zscore5.43
Residue begin1
Residue end100
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0415Gene nameConfidence Score
Rv0417thiG0.999
Rv0416thiS0.989
Rv0414cthiE0.956
Rv0423cthiC0.918
Rv0423cthiC0.918
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
polyglycinePubChem0.975.0666