Rv1485

Tuberculist information
Gene namehemZ
Protein functionFerrochelatase HemZ (protoheme ferro-lyase) (heme synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1675.02
Molecular mass(da)37144
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 344
	  		  	1    MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRT   60
			  	61   LIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDI  120
			  	121  ARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRGDARLVFTAHSIPTAADR  180
			  	181  RCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGIN  240
			  	241  AVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRY  300
			  	301  GRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 3 to 299  |  Coverage: 86% Ferrochelatase Range: 3 to 316  |  Coverage: 90% 1 Range: 1 to 334  |  Coverage: 96% 1
Number of amino acids : 344
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FerrochelatasePF007623-299
Mtb Structural Proteome models
Model Number1
Model nameRv1485
Template1HRK    APDBCREDO
Template coverage68_406
Template Identity(%)26.8
Model coverage(%)91.0
Normalized DOPE score-0.8

Structure Models from Chopin
Model Number1
Profilec.92.1.1
Click for model details
zscore50.35
Residue begin1
Residue end334
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1485Gene nameConfidence Score
Rv2677chemY0.999
Rv2677chemY0.999
Rv2678chemE0.998
Rv0512hemB0.99
Rv0509hemA0.984
Rv0509hemA0.984
Rv0509hemA0.984
Rv0524hemL0.983
Rv0510hemC0.981
Rv0510hemC0.981
Rv1451ctaB0.97
Rv2676cRv2676c0.961
Rv2388chemN0.959
Rv2388chemN0.959
Rv2850cRv2850c0.952
Rv2850cRv2850c0.952
Rv2847ccysG0.934
Rv2847ccysG0.934
Rv0958Rv09580.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Fe(III)PubChem0.97855.845
protoporphyrinPubChem0.963562.658
hemePubChem0.956616.487
protoporphyrinogen IXPubChem0.927568.706
vitamin K2PubChem0.9308.414
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
cobaltPubChem0.73117.866
zincPubChem0.72765.409