Rv2070c

Tuberculist information
Gene namecobK
Protein functionPrecorrin-6X reductase CobK
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2327.49
Molecular mass(da)25704.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 244
	  		  	1    VTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVRIGGFGGVEGLRGWLR   60
			  	61   EERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWDPGTAIIAVSDIEAADVVA  120
			  	121  EQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFAL  180
			  	181  LREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWVAG  240
			  	241  LPSR

Known structures in the PDB
No Known structures
1 25 49 73 97 121 145 169 193 217 241 Range: 2 to 241  |  Coverage: 97% CbiJ Range: 1 to 244  |  Coverage: 99% 1
Number of amino acids : 244
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CbiJPF025712-241
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profilec.87.1.7
Click for model details
zscore5.52
Residue begin1
Residue end244
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2070cGene nameConfidence Score
Rv2072ccobL0.999
Rv2072ccobL0.999
Rv2071ccobM0.999
Rv2066cobI0.994
Rv2062ccobN0.992
Rv2065cobH0.988
Rv2848ccobB0.964
Rv2848ccobB0.964
Rv0255ccobQ10.936
Rv0255ccobQ10.936
Rv2236ccobD0.93
Rv2207cobT0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
precorrin-6yPubChem0.967896.933
precorrin-6xPubChem0.966887.861
acetatePubChem0.90859.044
Precorrin 5PubChem0.9922.927
NADPPubChem0.9744.413
S-adenosyl-methioninePubChem0.9398.437
hydroxyl radicalsPubChem0.917.0073
Precorrin 6aPubChem0.9894.917
carbon dioxidePubChem0.944.0095
precorrin-8xPubChem0.9880.976
Precorrin 6bPubChem0.9896.933
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
NADP(H)PubChem0.9745.421
Precorrin 8xPubChem0.9880.976
S-adenosyl-L-methioninePubChem0.9399.445
S-adenosylhomocysteinePubChem0.9384.411
H(+)PubChem0.92.01588
precorrin-5PubChem0.9922.927