Rv0306

Tuberculist information
Gene nameRv0306
Protein functionPutative oxidoreductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)375.914
Molecular mass(da)24865.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 223
	  		  	1    MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAAPSVGLMQPWRFIRITD   60
			  	61   ETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAELLVVALCDRRGSYIFGRR  120
			  	121  TLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLAALLAMPADAEPVAILCLGPV  180
			  	181  PEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATDHHHGE

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 14 to 179  |  Coverage: 73% Nitroreductase Range: 10 to 223  |  Coverage: 95% 1 Range: 1 to 223  |  Coverage: 99% 1
Number of amino acids : 223
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NitroreductasePF0088114-179
Mtb Structural Proteome models
Model Number1
Model nameRv0306
Template1F5V    APDBCREDO
Template coverage4_195
Template Identity(%)23.4
Model coverage(%)95.5
Normalized DOPE score0.691

Structure Models from Chopin
Model Number1
Profiled.90.1.1 - 3.40.109.10
Click for model details
zscore22.29
Residue begin1
Residue end223
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0306Gene nameConfidence Score
Rv2207cobT0.976
Rv2062ccobN0.953
Rv0255ccobQ10.912
Rv0255ccobQ10.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00698DrugBankNitrofurantoin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
5,6-dimethylbenzimidazolePubChem0.949146.189
flavin mononucleotidePubChem0.876456.344
molecular oxygenPubChem0.75831.9988