Rv2064

Tuberculist information
Gene namecobG
Protein functionPrecorrin-3B synthase CobG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2321.45
Molecular mass(da)37496.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 363
	  		  	1    VAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFGSATLELTARG   60
			  	61   NVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLSGRAGGLADVRAWVGELDAAI  120
			  	121  RAEPRLAELGGRFWFGLDDGRADVSGLGADVGVQVFPDGPRLLLTGRDTGVRVADVAETL  180
			  	181  IEVALRFVKIRETAWRVTELADIGELQSGVELGPSVRPVTKTPVGWIPQDDSRVTLGAAV  240
			  	241  PLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAALRVLAPLGLVFDENSPWLN  300
			  	301  ISACTGSPGCAHSAADVRADAARSLNVESAGHRHFVGCERACGSPPAGEVLVATGGGYRR  360
			  	361  LRP

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 15 to 80  |  Coverage: 17% NIR_SIR_ferr Range: 19 to 351  |  Coverage: 91% 1 Range: 9 to 66  |  Coverage: 15% 1 Range: 23 to 80  |  Coverage: 15% 2 Range: 235 to 292  |  Coverage: 15% 3 Range: 9 to 66  |  Coverage: 15% 4
Number of amino acids : 363
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NIR_SIR_ferrPF0346015-80
Mtb Structural Proteome models
Model Number1
Model nameRv2064
Template1ZJ8    APDBCREDO
Template coverage90_476
Template Identity(%)24.0
Model coverage(%)91.2
Normalized DOPE score0.295

Structure Models from Chopin
Model Number1
Profile3.90.480.10
Click for model details
zscore11.63
Residue begin9
Residue end66
Model Number2
Profile3.90.480.10
Click for model details
zscore11.63
Residue begin23
Residue end80
Model Number3
Profile3.90.480.10
Click for model details
zscore11.63
Residue begin235
Residue end292
Model Number4
Profiled.134.1.1, d.58.36.1 - 3.30.413.10, 3.90.480.10
Click for model details
zscore9.44
Residue begin9
Residue end66
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2064Gene nameConfidence Score
Rv2066cobI0.998
Rv2065cobH0.993
Rv2062ccobN0.976
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C06406PubChem0.9894.874
C05772PubChem0.9878.874