Rv0646c

Tuberculist information
Gene namelipG
Protein functionProbable lipase/esterase LipG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)740.234
Molecular mass(da)32931
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 301
	  		  	1    VDIRSGTAVSGDVKLYYEDMGDLDHPPVLLIMGLGAQMLLWRTDFCARLVAKGLRVIRYD   60
			  	61   NRDVGLSTKTERHRPGQPLATRLVRSWLGLPSQAAYTLEDMAADAAALLDHLDVKHAHVV  120
			  	121  GASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLALLTGPPPDSPRDVIV  180
			  	181  DNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQFSAILGSGSLLRYDRRIV  240
			  	241  APTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMGHDLPRQLWDRVIGELTRNFSEA  300
			  	301  G

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 28 to 292  |  Coverage: 87% Abhydrolase_6 Range: 17 to 300  |  Coverage: 94% 1 Range: 4 to 301  |  Coverage: 98% 1
Number of amino acids : 301
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Abhydrolase_6PF1269728-292
Mtb Structural Proteome models
Model Number1
Model nameRv0646c
Template1IUP    APDBCREDO
Template coverage19_273
Template Identity(%)25.1
Model coverage(%)94.0
Normalized DOPE score-0.18

Structure Models from Chopin
Model Number1
Profilec.69.1.28 - 3.40.50.1820
Click for model details
zscore50.53
Residue begin4
Residue end301
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0646cGene nameConfidence Score
Rv0255ccobQ10.904
Rv0255ccobQ10.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions