SInCRe - Rv0527

Tuberculist information

Gene name	ccdA
Protein function	Possible cytochrome C-type biogenesis protein CcdA
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	617.493
Molecular mass(da)	26488.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 259

	  		  	1    MTGFTEIAAVGPLLVAVGVCLLAGLVSFASPCVVPLVPGYLSYLAAVVGVDEQLPAGVVK   60
			  	61   PPVAARWRVAGSAALFVAGFTTVFVLGTVAVLGMTTTLITNQLLLQRVGGVLIVVMGLVF  120
			  	121  VGFIGALQRQARFTPRQLTSVAGAPVLGAVFALGWTPCLGPTLTGVITVASATEGASVAR  180
			  	181  GIVLVIAYCLGLGIPFVLLAFGSAWAVAGLGWLRRHTRAIQIFGGALLIAVGAALVTGVW  240
			  	241  NDVVSWLRDAFVSDVRLPI

Known structures in the PDB

No Known structures

Number of amino acids : 259

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
DsbD	PF02683	20-237

Mtb Structural Proteome models

Model Number	1
Model name	Rv0527
Template	1YO8 APDB CREDO
Template coverage	1003_1170
Template Identity(%)	10.7
Model coverage(%)	79.5
Normalized DOPE score	1.536

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0527	Gene name	Confidence Score
Rv0526	Rv0526	0.998
Rv2678c	hemE	0.96
Rv1677	dsbF	0.944
Rv2874	dipZ	0.942
Rv2874	dipZ	0.942
Rv0529	ccsA	0.941
Rv3914	trxC	0.928
Rv0524	hemL	0.927

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions