Rv2874

Tuberculist information
Gene namedipZ
Protein functionPossible integral membrane C-type cytochrome biogenesis protein DipZ
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3184.85
Molecular mass(da)74168.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 695
	  		  	1    MVESRRAAAAASAYASRCGIAPATSQRSLATPPTISVPSGEGRCRCHVARGAGRDPRRRL   60
			  	61   RRRRWCGRCGYHSHLTGGEFDVNRLCQQRSRERSCQLVAVPADPRPKRQRITDVLTLALV  120
			  	121  GFLGGLITGISPCILPVLPVIFFSGAQSVDAAQVAKPEGAVAVRRKRALSATLRPYRVIG  180
			  	181  GLVLSFGMVTLLGSALLSVLHLPQDAIRWAALVALVAIGAGLIFPRFEQLLEKPFSRIPQ  240
			  	241  KQIVTRSNGFGLGLALGVLYVPCAGPILAAIVVAGATATIGLGTVVLTATFALGAALPLL  300
			  	301  FFALAGQRIAERVGAFRRRQREIRIATGSVTILLAVALVFDLPAALQRAIPDYTASLQQQ  360
			  	361  ISTGTEIREQLNLGGIVNAQNAQLSNCSDGAAQLESCGTAPDLKGITGWLNTPGNKPIDL  420
			  	421  KSLRGKVVLIDFWAYSCINCQRAIPHVVGWYQAYKDSGLAVIGVHTPEYAFEKVPGNVAK  480
			  	481  GAANLGISYPIALDNNYATWTNYRNRYWPAEYLIDATGTVRHIKFGEGDYNVTETLVRQL  540
			  	541  LNDAKPGVKLPQPSSTTTPDLTPRAALTPETYFGVGKVVNYGGGGAYDEGSAVFDYPPSL  600
			  	601  AANSFALRGRWALDYQGATSDGNDAAIKLNYHAKDVYIVVGGTGTLTVVRDGKPATLPIS  660
			  	661  GPPTTHQVVAGYRLASETLEVRPSKGLQVFSFTYG

Known structures in the PDB
PDB ID2HYX
Total residue count1408
Number of chains4
MethodX-RAY
Resolution1.9
1 70 139 208 277 346 415 484 553 622 691 Range: 121 to 340  |  Coverage: 31% DsbD Range: 398 to 523  |  Coverage: 17% AhpC-TSA Range: to 3  |  Coverage: 0% 1 Range: 398 to 543  |  Coverage: 20% 2 Range: 398 to 516  |  Coverage: 16% 1
Number of amino acids : 695
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DsbDPF02683121-340
AhpC-TSAPF00578398-523
Mtb Structural Proteome models
Model Number1
Model nameRv2874_2hyx_A
Template2HYX    APDBCREDO
Template coverage0_695
Template Identity(%)100.0
Model coverage(%)100.0
Normalized DOPE score-1.587

Model Number2
Model nameRv2874
Template2F9S    APDBCREDO
Template coverage40_175
Template Identity(%)23.5
Model coverage(%)20.9
Normalized DOPE score-1.325

Structure Models from Chopin
Model Number1
Profilec.47.1.16 - 3.40.30.10
Click for model details
zscore5.09
Residue begin398
Residue end516
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2874Gene nameConfidence Score
Rv0527ccdA0.942
Rv2875mpt700.926
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions