SInCRe - Rv1932

Tuberculist information

Gene name	tpx
Protein function	Probable thiol peroxidase Tpx
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	2183.37
Molecular mass(da)	16896.1
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 165

	  		  	1    MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGKSVLLNIFPSVDTPVC   60
			  	61   ATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVMPASAFRDSFGEDYGVTIA  120
			  	121  DGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAALAALGA

Known structures in the PDB

	PDB ID	1XVQ
	Total residue count	175
	Number of chains	1
	Method	X-RAY
	Resolution	1.75

	PDB ID	1Y25
	Total residue count	330
	Number of chains	2
	Method	X-RAY
	Resolution	2.1

Number of amino acids : 165

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Redoxin	PF08534	19-160

Mtb Structural Proteome models

Model Number	1
Model name	Rv1932_1xvq_A
Template	1XVQ APDB CREDO
Template coverage	2_167
Template Identity(%)	100.0
Model coverage(%)	100.0
Normalized DOPE score	-1.394

Model Number	2
Model name	Rv1932
Template	1XVQ APDB CREDO
Template coverage	2_165
Template Identity(%)	98.7
Model coverage(%)	98.8
Normalized DOPE score	-0.782

Structure Models from Chopin

Model Number	1
Profile	c.47.1.10 - 3.40.30.10 Click for model details
zscore	8.69
Residue begin	1
Residue end	165

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1932	Gene name	Confidence Score
Rv3913	trxB2	0.984
Rv3913	trxB2	0.984
Rv3914	trxC	0.982
Rv1471	trxB1	0.957

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
hydrogen peroxidePubChem	0.971	34.0147
acetatePubChem	0.93	59.044
hydroxyl radicalsPubChem	0.915	17.0073
ammoniaPubChem	0.9	17.0305
yttriumPubChem	0.9	88.9059
hydride acetatePubChem	0.9	61.0599
DB03382PubChem	0.8	136.15
sulfatePubChem	0.743	96.0626
chloridePubChem	0.71	35.453
hydron sulfatePubChem	0.704	196.157
citratePubChem	0.703	192.124