Rv1470

Tuberculist information
Gene nametrxA
Protein functionProbable thioredoxin TrxA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1658.98
Molecular mass(da)13439.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 124
	  		  	1    VTTRDLTAAYFQQTISANSNVLVYFWAPLCAPCDLFTPTYEASSRKHFDVVHGKVNIETE   60
			  	61   KDLASIAGVKLLPTLMAFKKGKLVFKQAGIANPAIMDNLVQQLRAYTFKSPAGEGIGPGT  120
			  	121  KTSS

Known structures in the PDB
PDB ID2I1U
Total residue count121
Number of chains1
MethodX-RAY
Resolution1.3
PDB ID2L4Q
Total residue count116
Number of chains1
MethodNMR
ResolutionN/A
PDB ID2L59
Total residue count116
Number of chains1
MethodNMR
ResolutionN/A
PDB ID3O6T
Total residue count472
Number of chains4
MethodX-RAY
Resolution2.4
1 13 25 37 49 61 73 85 97 109 121 Range: 8 to 111  |  Coverage: 83% Thioredoxin Range: 2 to 105  |  Coverage: 83% 1 Range: 1 to 124  |  Coverage: 99% 1
Number of amino acids : 124
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ThioredoxinPF000858-111
Mtb Structural Proteome models
Model Number1
Model nameRv1470
Template1NSW    APDBCREDO
Template coverage1_105
Template Identity(%)30.8
Model coverage(%)83.1
Normalized DOPE score-0.891

Structure Models from Chopin
Model Number1
Profilec.47.1.8 - 3.40.30.10
Click for model details
zscore20.08
Residue begin1
Residue end124
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1470Gene nameConfidence Score
Rv3913trxB20.965
Rv3913trxB20.965
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions