Rv0728c

Tuberculist information
Gene nameserA2
Protein functionPossible D-3-phosphoglycerate dehydrogenase SerA2 (phosphoglycerate dehydrogenase) (PGDH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)820.496
Molecular mass(da)34407.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 326
	  		  	1    VTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVV   60
			  	61   ESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLA  120
			  	121  VARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLR  180
			  	181  VIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQ  240
			  	241  LRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQAR  300
			  	301  MVADDLGALLSGNRPAHVVNPEVLGS

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 15 to 320  |  Coverage: 93% 2-Hacid_dh Range: 115 to 288  |  Coverage: 53% 2-Hacid_dh_C Range: 3 to 324  |  Coverage: 98% 1 Range: 115 to 288  |  Coverage: 53% 1
Number of amino acids : 326
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
2-Hacid_dhPF0038915-320
2-Hacid_dh_CPF02826115-288
Mtb Structural Proteome models
Model Number1
Model nameRv0728c
Template2DBQ    APDBCREDO
Template coverage1_326
Template Identity(%)34.8
Model coverage(%)98.5
Normalized DOPE score-0.297

Structure Models from Chopin
Model Number1
Profilec.2.1.4
Click for model details
zscore26.82
Residue begin115
Residue end288
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0728cGene nameConfidence Score
Rv0884cserC0.989
Rv1617pykA0.982
Rv1617pykA0.982
Rv2205cRv2205c0.933
Rv0489gpm10.932
Rv0727cfucA0.915
Rv3214gpm20.911
Rv2419cRv2419c0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.976663.425
D-lactatePubChem0.96390.0779
lactatePubChem0.96390.0779
phosphohydroxypyruvatePubChem0.948184.041
propionatePubChem0.93774.0785
alpha-ketoglutaratePubChem0.931146.098
3-phosphoglyceratePubChem0.929186.057
L-alaninePubChem0.92389.0932
reduced nicotinamide adenine dinucleotidePubChem0.918665.441
glutamatePubChem0.915147.129
H(+)PubChem0.9022.01588
deuteriumPubChem0.9012.01588
lactyl-CoAPubChem0.9839.597
adenosine triphosphatePubChem0.9507.181
phosphoenolpyruvatePubChem0.9168.042
n-propionyl-CoAPubChem0.9823.597
propionyl-CoAPubChem0.9823.597
protiumPubChem0.92.01576
adenosine diphosphatePubChem0.9427.201
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
pyruvic acidPubChem0.988.0621
D-lactoyl-CoAPubChem0.9835.565
glyceratePubChem0.755106.077
sulfatePubChem0.72496.0626