SInCRe - Rv0727c

Tuberculist information

Gene name	fucA
Protein function	Possible L-fuculose phosphate aldolase FucA (L-fuculose-1-phosphate aldolase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	819.843
Molecular mass(da)	23066.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 218

	  		  	1    MNFVDAPESAVLAAAKDMLRRGLVEGTAGNISARRSDGNVVITPSSVDYAEMLLHDLVLV   60
			  	61   DAGGAVLHAKDGRSPSTELNLHLACYRAFDDIGSVIHSHPVWATMFAVAHEPIPACIDEF  120
			  	121  AIYCGGDVRCTEYAASGTPEVGRNAVRALEGRAAALIANHGLVAVGPRPDQVLRVTALVE  180
			  	181  RTAQIVWGARALGGPVPIPEDVCRNFTGVYGYLRANPL

Known structures in the PDB

No Known structures

Number of amino acids : 218

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aldolase_II	PF00596	9-187

Mtb Structural Proteome models

Model Number	1
Model name	Rv0727c
Template	1E4C PPDB CREDO
Template coverage	1_206
Template Identity(%)	29.6
Model coverage(%)	95.9
Normalized DOPE score	-0.758

Structure Models from Chopin

Model Number	1
Profile	3.40.225.10 Click for model details
zscore	40.82
Residue begin	2
Residue end	213

Binding pockets

STRING

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Protein interacting with Rv0727c	Gene name	Confidence Score
Rv0728c	serA2	0.915
Rv0728c	serA2	0.915

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions