Rv1862

Tuberculist information
Gene nameadhA
Protein functionProbable alcohol dehydrogenase AdhA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2109.54
Molecular mass(da)36631.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 346
	  		  	1    MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEG   60
			  	61   DLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSE  120
			  	121  NLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELP  180
			  	181  PGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAADRPPVPL  240
			  	241  DAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLNYQQHLFQERQIRSVTSNTRA  300
			  	301  DARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAGAAVLLI

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 38 to 151  |  Coverage: 32% ADH_N Range: 192 to 311  |  Coverage: 34% ADH_zinc_N Range: 10 to 346  |  Coverage: 97% 1 Range: 1 to 346  |  Coverage: 99% 1 Range: 38 to 151  |  Coverage: 32% 2 Range: 1 to 336  |  Coverage: 96% 3 Range: 161 to 321  |  Coverage: 46% 4
Number of amino acids : 346
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ADH_NPF0824038-151
ADH_zinc_NPF00107192-311
Mtb Structural Proteome models
Model Number1
Model nameRv1862
Template1RJW    APDBCREDO
Template coverage1_336
Template Identity(%)33.0
Model coverage(%)97.1
Normalized DOPE score-0.372

Structure Models from Chopin
Model Number1
Profile3.40.50.720, 3.90.180.10
Click for model details
zscore31.33
Residue begin1
Residue end346
Model Number2
Profile3.90.180.10
Click for model details
zscore21.71
Residue begin38
Residue end151
Model Number3
Profile3.90.180.10
Click for model details
zscore15.52
Residue begin1
Residue end336
Model Number4
Profilec.2.1.1 - 3.40.50.720
Click for model details
zscore12.38
Residue begin161
Residue end321
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1862Gene nameConfidence Score
Rv0458Rv04580.918
Rv2858caldC0.909
Rv0223cRv0223c0.908
Rv0768aldA0.907
Rv3252calkB0.905
Rv0147Rv01470.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.941663.425
acetaldehydePubChem0.93944.0526
methanolPubChem0.92730.026
reduced nicotinamide adenine dinucleotidePubChem0.907665.441
H(+)PubChem0.9062.01588
deuteriumPubChem0.9052.01588
3,4-dihydroxyphenylglycolPubChem0.9170.163
3,4-dihydroxyphenylglycolaldehydePubChem0.9168.147
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
1-naphthalenecarboxaldehydePubChem0.9156.181
protiumPubChem0.92.01576
1-hydroxymethylnaphthalenePubChem0.9158.197
2-hydroxymethylnaphthalenePubChem0.9158.197
trans-3-chloroallyl alcoholPubChem0.992.5242
NSC508744PubChem0.992.5242
2-naphthaldehydePubChem0.9156.181
C16348PubChem0.990.5083
3-chloro-2-PropenalPubChem0.990.5083