SInCRe - Rv3521

Tuberculist information

Gene name	Rv3521
Protein function	Conserved hypothetical protein
Functional category(tuberculist)	conserved hypotheticals
Gene location(kb)	3957.52
Molecular mass(da)	32970.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 303

	  		  	1    VGPTLSRFFTALRARRIVGVRGSDGRVHVPPVEYDPVTYEPLSEMVPVSSVGTVASWTWQ   60
			  	61   PEPLAGQPLDRPFAWALIKLDGADTLLMHAVDVGTAGPSAIHTGARVHAHWADQPVGAIT  120
			  	121  DIACFALGETAEPVAAHKTEDARDPVTMIVTPIQLEIQHTASHEESAYLRAIAQGKLVGA  180
			  	181  RTGKTGKVYFPPHGADPATGKPTSEFVELPDKGTVTTFAIVNIPFLGQRIKPPYVAAYVL  240
			  	241  LDGADIPFLHLVSDVDAHQVRMGMRVEAVWKPRERWGLGIDNIEYFRPTGEPDANYDTYK  300
			  	301  HHL

Known structures in the PDB

No Known structures

Number of amino acids : 303

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
DUF35	PF01796	45-112
DUF35	PF01796	206-271

Mtb Structural Proteome models

Model Number	1
Model name	Rv3521
Template	2GNR APDB CREDO
Template coverage	28_132
Template Identity(%)	24.8
Model coverage(%)	35.6
Normalized DOPE score	0.034

Model Number	2
Model name	Rv3521.2
Template	2GNR APDB CREDO
Template coverage	8_136
Template Identity(%)	14.0
Model coverage(%)	42.6
Normalized DOPE score	0.229

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3521	Gene name	Confidence Score
Rv3522	ltp4	0.953
Rv3523	ltp3	0.952

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv3521.2	4	3cs9_NIL_C_600 PDB CREDO	0.807	0.022	0.644	0.001
Rv3521.2	4	2nnk_ROC_A_401 PDB CREDO	0.657	0.117	0.642	0.001
Rv3521.2	4	3cs9_NIL_D_600 PDB CREDO	0.799	0.025	0.638	0.001
Rv3521.2	4	3ndt_ROC_D_100 PDB CREDO	0.652	0.123	0.636	0.001
Rv3521.2	4	2avv_MK1_E_902 PDB CREDO	0.632	0.142	0.632	0.001
Rv3521.2	4	3k4v_ROC_D_201 PDB CREDO	0.642	0.133	0.627	0.001
Rv3521.2	4	3el4_ROC_A_100 PDB CREDO	0.625	0.150	0.625	0.001
Rv3521.2	4	2avv_MK1_A_901 PDB CREDO	0.621	0.154	0.621	0.001
Rv3521.2	4	1c6z_ROC_B_505 PDB CREDO	0.672	0.104	0.610	0.002
Rv3521.2	4	2fxd_DR7_A_102 PDB CREDO	0.777	0.034	0.604	0.002
Rv3521.2	4	3ndu_ROC_D_100 PDB CREDO	0.642	0.132	0.599	0.002
Rv3521.2	4	3cs9_NIL_B_600 PDB CREDO	0.791	0.028	0.599	0.002
Rv3521.2	4	2o4k_DR7_A_301 PDB CREDO	0.625	0.150	0.597	0.002
Rv3521.2	4	3cs9_NIL_A_600 PDB CREDO	0.809	0.022	0.596	0.002
Rv3521.2	3	3k54_1N1_A_1 PDB CREDO	0.641	0.134	0.595	0.002
Rv3521.2	4	3d1y_ROC_A_201 PDB CREDO	0.638	0.136	0.594	0.002
Rv3521.2	3	3qlg_1N1_B_601 PDB CREDO	0.617	0.159	0.594	0.002
Rv3521.2	4	1opj_STI_A_3 PDB CREDO	0.806	0.022	0.594	0.002
Rv3521.2	3	3g5d_1N1_A_1 PDB CREDO	0.616	0.160	0.593	0.002
Rv3521.2	3	3qlg_1N1_A_601 PDB CREDO	0.615	0.162	0.591	0.002
Rv3521.2	4	3gp0_NIL_A_1 PDB CREDO	0.720	0.066	0.590	0.003
Rv3521.2	3	3kw2_ADN_A_300 PDB CREDO	0.612	0.164	0.590	0.003
Rv3521.2	4	2qxs_RAL_B_600 PDB CREDO	0.779	0.033	0.589	0.003
Rv3521.2	4	1k6c_MK1_B_902 PDB CREDO	0.589	0.193	0.589	0.003
Rv3521.2	4	1sdt_MK1_B_902 PDB CREDO	0.616	0.160	0.587	0.003
Rv3521.2	4	3el9_DR7_A_100 PDB CREDO	0.756	0.045	0.587	0.003
Rv3521.2	4	1opj_STI_B_4 PDB CREDO	0.797	0.026	0.587	0.003
Rv3521.2	4	2nmy_ROC_A_401 PDB CREDO	0.643	0.132	0.586	0.003
Rv3521.2	4	2qxs_RAL_A_600 PDB CREDO	0.774	0.035	0.586	0.003
Rv3521.2	3	3g5d_1N1_B_1 PDB CREDO	0.607	0.171	0.584	0.003
Rv3521.2	4	1t7i_017_A_200 PDB CREDO	0.584	0.199	0.584	0.003
Rv3521.2	4	3pwr_ROC_A_401 PDB CREDO	0.612	0.165	0.583	0.003
Rv3521.2	3	2cbr_A80_A_201 PDB CREDO	0.604	0.174	0.581	0.003
Rv3521.2	3	2zva_1N1_A_513 PDB CREDO	0.626	0.149	0.579	0.003
Rv3521.2	4	3oxx_DR7_C_100 PDB CREDO	0.622	0.153	0.579	0.003
Rv3521.2	4	3s56_ROC_A_201 PDB CREDO	0.744	0.051	0.578	0.003
Rv3521.2	3	1kij_NOV_B_444 PDB CREDO	0.578	0.207	0.578	0.003
Rv3521.2	3	2gqg_1N1_A_501 PDB CREDO	0.644	0.131	0.576	0.003
Rv3521.2	4	1hxb_ROC_A_100 PDB CREDO	0.634	0.140	0.576	0.003
Rv3521.2	3	2fum_MIX_A_539 PDB CREDO	0.643	0.131	0.575	0.003
Rv3521.2	4	1rl8_RIT_A_9001 PDB CREDO	0.618	0.158	0.575	0.003
Rv3521.2	4	2r5p_MK1_D_902 PDB CREDO	0.684	0.094	0.575	0.003
Rv3521.2	4	3ufn_ROC_A_401 PDB CREDO	0.700	0.081	0.574	0.003
Rv3521.2	4	2r5p_MK1_B_902 PDB CREDO	0.682	0.096	0.573	0.003
Rv3521.2	4	2aqu_DR7_B_300 PDB CREDO	0.646	0.129	0.572	0.003
Rv3521.2	4	3oxx_DR7_A_100 PDB CREDO	0.645	0.129	0.571	0.004
Rv3521.2	4	2fxe_DR7_A_102 PDB CREDO	0.678	0.098	0.571	0.004
Rv3521.2	4	3eky_DR7_A_100 PDB CREDO	0.678	0.098	0.571	0.004
Rv3521.2	4	3em4_DR7_V_100 PDB CREDO	0.678	0.098	0.571	0.004
Rv3521.2	4	3ucb_017_A_201 PDB CREDO	0.584	0.198	0.571	0.004
Rv3521.2	4	3rgf_BAX_A_465 PDB CREDO	0.814	0.020	0.567	0.004
Rv3521.2	3	3kw2_ADN_B_300 PDB CREDO	0.613	0.164	0.567	0.004
Rv3521.2	4	2q64_1UN_B_1001 PDB CREDO	0.624	0.151	0.566	0.004
Rv3521.2	4	1hxw_RIT_B_301 PDB CREDO	0.673	0.103	0.566	0.004
Rv3521.2	4	2qak_1UN_A_1001 PDB CREDO	0.623	0.153	0.565	0.004
Rv3521.2	4	2nnp_ROC_A_401 PDB CREDO	0.564	0.224	0.564	0.004
Rv3521.2	4	2pym_1UN_A_1001 PDB CREDO	0.622	0.154	0.564	0.004
Rv3521.2	4	1sdv_MK1_B_902 PDB CREDO	0.706	0.076	0.564	0.004
Rv3521.2	4	2pyn_1UN_A_1001 PDB CREDO	0.619	0.156	0.562	0.004
Rv3521.2	4	2q63_1UN_A_1001 PDB CREDO	0.619	0.156	0.562	0.004
Rv3521.2	4	1tco_FK5_C_509 PDB CREDO	0.650	0.124	0.561	0.004
Rv3521.2	4	3ogq_AB1_A_200 PDB CREDO	0.650	0.124	0.561	0.004
Rv3521.2	4	3sm2_478_A_126 PDB CREDO	0.632	0.143	0.559	0.004
Rv3521.2	4	3k5v_STI_A_2 PDB CREDO	0.779	0.033	0.558	0.004
Rv3521.2	4	3oxc_ROC_A_401 PDB CREDO	0.667	0.109	0.556	0.005
Rv3521.2	3	3oht_1N1_A_1000 PDB CREDO	0.577	0.208	0.556	0.005
Rv3521.2	4	1ya4_CTX_A_1 PDB CREDO	0.582	0.201	0.555	0.005
Rv3521.2	4	1t46_STI_A_3 PDB CREDO	0.694	0.085	0.554	0.005
Rv3521.2	3	2fum_MIX_B_1539 PDB CREDO	0.623	0.153	0.554	0.005
Rv3521.2	3	3bbt_FMM_B_91 PDB CREDO	0.554	0.239	0.554	0.005
Rv3521.2	4	3tkg_ROC_C_901 PDB CREDO	0.580	0.204	0.553	0.005
Rv3521.2	3	2fum_MIX_D_3539 PDB CREDO	0.686	0.092	0.552	0.005
Rv3521.2	4	3ggu_017_B_201 PDB CREDO	0.656	0.119	0.552	0.005
Rv3521.2	3	2fum_MIX_C_2539 PDB CREDO	0.596	0.184	0.552	0.005
Rv3521.2	4	1c6y_MK1_B_524 PDB CREDO	0.708	0.075	0.550	0.005
Rv3521.2	4	3cyx_ROC_A_201 PDB CREDO	0.589	0.193	0.549	0.005
Rv3521.2	4	3k4v_ROC_B_201 PDB CREDO	0.700	0.081	0.548	0.005
Rv3521.2	4	3oez_STI_A_601 PDB CREDO	0.807	0.022	0.546	0.005
Rv3521.2	3	2uxo_TAC_B_1211 PDB CREDO	0.614	0.163	0.546	0.005
Rv3521.2	4	3pyy_STI_B_4 PDB CREDO	0.806	0.023	0.545	0.005
Rv3521.2	4	3bvb_017_B_401 PDB CREDO	0.572	0.215	0.545	0.005
Rv3521.2	4	1hsh_MK1_A_401 PDB CREDO	0.701	0.080	0.545	0.005
Rv3521.2	4	1hsh_MK1_C_402 PDB CREDO	0.700	0.081	0.544	0.005
Rv3521.2	4	3ekq_ROC_A_100 PDB CREDO	0.719	0.067	0.544	0.006
Rv3521.2	4	2f80_017_B_301 PDB CREDO	0.598	0.182	0.543	0.006
Rv3521.2	3	3oct_1N1_A_663 PDB CREDO	0.650	0.124	0.542	0.006
Rv3521.2	4	2hyy_STI_D_600 PDB CREDO	0.801	0.024	0.542	0.006
Rv3521.2	4	3mss_STI_D_1 PDB CREDO	0.801	0.024	0.542	0.006
Rv3521.2	4	3pyy_STI_A_3 PDB CREDO	0.800	0.025	0.541	0.006
Rv3521.2	4	2hyy_STI_C_600 PDB CREDO	0.800	0.025	0.541	0.006
Rv3521.2	4	3em4_DR7_A_100 PDB CREDO	0.696	0.084	0.541	0.006
Rv3521.2	4	3mss_STI_A_1 PDB CREDO	0.800	0.025	0.541	0.006
Rv3521.2	4	2hyy_STI_A_600 PDB CREDO	0.799	0.025	0.541	0.006
Rv3521.2	4	3mss_STI_C_1 PDB CREDO	0.799	0.025	0.540	0.006
Rv3521.2	4	3k5v_STI_B_2 PDB CREDO	0.798	0.025	0.540	0.006
Rv3521.2	4	3mss_STI_B_1 PDB CREDO	0.798	0.025	0.540	0.006
Rv3521.2	4	1iep_STI_B_202 PDB CREDO	0.798	0.026	0.539	0.006
Rv3521.2	4	3ms9_STI_B_1 PDB CREDO	0.798	0.026	0.539	0.006
Rv3521.2	4	1iep_STI_A_201 PDB CREDO	0.797	0.026	0.539	0.006
Rv3521.2	4	3ms9_STI_A_1 PDB CREDO	0.796	0.026	0.539	0.006
Rv3521.2	4	3gvu_STI_A_1001 PDB CREDO	0.795	0.027	0.538	0.006
Rv3521.2	4	3ndt_ROC_A_101 PDB CREDO	0.701	0.080	0.537	0.006
Rv3521.2	3	3fuu_ADN_A_0 PDB CREDO	0.557	0.234	0.536	0.006
Rv3521.2	3	1jzs_MRC_A_1301 PDB CREDO	0.536	0.265	0.536	0.006
Rv3521.2	4	3ekx_1UN_B_201 PDB CREDO	0.620	0.156	0.535	0.006
Rv3521.2	4	3d1z_017_B_201 PDB CREDO	0.548	0.247	0.535	0.006
Rv3521.2	3	1mx1_THA_F_6 PDB CREDO	0.577	0.207	0.534	0.006
Rv3521.2	4	1sh9_RIT_B_301 PDB CREDO	0.686	0.091	0.534	0.007
Rv3521.2	3	3sxr_1N1_A_1 PDB CREDO	0.576	0.208	0.533	0.007
Rv3521.2	4	1xkk_FMM_A_91 PDB CREDO	0.633	0.142	0.532	0.007
Rv3521.2	4	2xkw_P1B_A_1478 PDB CREDO	0.617	0.159	0.532	0.007
Rv3521.2	4	2hs2_017_A_201 PDB CREDO	0.545	0.251	0.532	0.007
Rv3521.2	4	3tkg_ROC_B_801 PDB CREDO	0.664	0.111	0.531	0.007
Rv3521.2	3	4eb4_D16_B_402 PDB CREDO	0.530	0.273	0.530	0.007
Rv3521.2	3	3ti1_B49_A_299 PDB CREDO	0.550	0.244	0.529	0.007
Rv3521.2	3	1fmo_ADN_E_351 PDB CREDO	0.593	0.187	0.528	0.007
Rv3521.2	4	2pl0_STI_A_200 PDB CREDO	0.852	0.010	0.527	0.007
Rv3521.2	4	2avo_MK1_B_902 PDB CREDO	0.581	0.203	0.527	0.007
Rv3521.2	4	3prs_RIT_A_1001 PDB CREDO	0.565	0.223	0.526	0.007
Rv3521.2	4	3jw2_017_A_401 PDB CREDO	0.538	0.261	0.525	0.007
Rv3521.2	4	3ndw_RIT_A_100 PDB CREDO	0.565	0.224	0.525	0.007
Rv3521.2	3	1s9p_DES_B_459 PDB CREDO	0.567	0.221	0.525	0.007
Rv3521.2	3	1s9p_DES_C_500 PDB CREDO	0.566	0.222	0.524	0.008
Rv3521.2	3	2ito_IRE_A_2020 PDB CREDO	0.524	0.282	0.524	0.008
Rv3521.2	4	1ohr_1UN_A_201 PDB CREDO	0.674	0.102	0.524	0.008
Rv3521.2	4	3ekw_DR7_B_100 PDB CREDO	0.605	0.173	0.522	0.008
Rv3521.2	4	2avs_MK1_B_902 PDB CREDO	0.575	0.210	0.522	0.008
Rv3521.2	3	3oht_1N1_B_1000 PDB CREDO	0.604	0.174	0.521	0.008
Rv3521.2	4	3ndx_RIT_A_100 PDB CREDO	0.521	0.286	0.521	0.008
Rv3521.2	4	3el0_1UN_A_201 PDB CREDO	0.727	0.062	0.520	0.008
Rv3521.2	4	2ieo_017_A_402 PDB CREDO	0.532	0.269	0.520	0.008
Rv3521.2	3	3sxr_1N1_B_2 PDB CREDO	0.584	0.198	0.520	0.008
Rv3521.2	3	3erd_DES_A_600 PDB CREDO	0.581	0.203	0.519	0.008
Rv3521.2	3	1s9p_DES_A_459 PDB CREDO	0.602	0.177	0.519	0.008
Rv3521.2	4	1sdu_MK1_B_902 PDB CREDO	0.602	0.177	0.519	0.008
Rv3521.2	4	3lzv_017_A_200 PDB CREDO	0.724	0.064	0.518	0.008
Rv3521.2	3	1mx1_THA_D_4 PDB CREDO	0.560	0.230	0.518	0.008
Rv3521.2	4	1hsg_MK1_B_902 PDB CREDO	0.666	0.109	0.518	0.008
Rv3521.2	3	2ity_IRE_A_2020 PDB CREDO	0.558	0.232	0.517	0.008
Rv3521.2	4	3el1_DR7_A_100 PDB CREDO	0.598	0.182	0.516	0.009
Rv3521.2	3	3adx_IMN_B_3 PDB CREDO	0.580	0.204	0.515	0.009
Rv3521.2	4	2b60_RIT_B_100 PDB CREDO	0.627	0.148	0.514	0.009
Rv3521.2	4	1n49_RIT_B_301 PDB CREDO	0.698	0.082	0.514	0.009
Rv3521.2	4	4asd_BAX_A_1500 PDB CREDO	0.803	0.024	0.513	0.009
Rv3521.2	3	1lhu_EST_A_301 PDB CREDO	0.593	0.188	0.512	0.009
Rv3521.2	3	1mx1_THA_E_5 PDB CREDO	0.551	0.243	0.511	0.009
Rv3521.2	4	3el5_1UN_B_201 PDB CREDO	0.577	0.208	0.511	0.009
Rv3521.2	3	3k2h_LYA_A_514 PDB CREDO	0.530	0.272	0.510	0.009
Rv3521.2	4	3cyw_017_A_201 PDB CREDO	0.510	0.303	0.510	0.009
Rv3521.2	4	3s43_478_A_401 PDB CREDO	0.548	0.247	0.510	0.009
Rv3521.2	4	3d20_017_A_201 PDB CREDO	0.534	0.267	0.510	0.009
Rv3521.2	3	1m17_AQ4_A_999 PDB CREDO	0.597	0.183	0.509	0.009
Rv3521.2	4	2bpx_MK1_B_902 PDB CREDO	0.711	0.072	0.509	0.009
Rv3521.2	4	3t3c_017_A_201 PDB CREDO	0.673	0.103	0.509	0.009
Rv3521.2	4	2hyy_STI_B_600 PDB CREDO	0.821	0.018	0.509	0.010
Rv3521.2	4	2jfa_RAL_B_600 PDB CREDO	0.872	0.006	0.508	0.010
Rv3521.2	3	1kij_NOV_A_400 PDB CREDO	0.630	0.145	0.507	0.010
Rv3521.2	3	1g50_EST_A_600 PDB CREDO	0.571	0.216	0.507	0.010
Rv3521.2	3	2zia_CL9_A_401 PDB CREDO	0.527	0.277	0.507	0.010
Rv3521.2	4	3tl9_ROC_A_401 PDB CREDO	0.582	0.201	0.507	0.010
Rv3521.2	4	1t3r_017_A_1200 PDB CREDO	0.532	0.270	0.507	0.010
Rv3521.2	3	2itz_IRE_A_2021 PDB CREDO	0.569	0.218	0.506	0.010
Rv3521.2	4	3nuj_478_B_401 PDB CREDO	0.557	0.234	0.506	0.010
Rv3521.2	3	4eb4_D16_A_402 PDB CREDO	0.544	0.252	0.505	0.010
Rv3521.2	4	1err_RAL_B_600 PDB CREDO	0.865	0.007	0.504	0.010
Rv3521.2	4	3nu4_478_B_401 PDB CREDO	0.632	0.143	0.504	0.010
Rv3521.2	4	3nu6_478_B_401 PDB CREDO	0.666	0.110	0.504	0.010
Rv3521.2	4	3nuo_478_B_478 PDB CREDO	0.614	0.162	0.504	0.010
Rv3521.2	4	3ogp_017_B_200 PDB CREDO	0.744	0.051	0.503	0.010
Rv3521.2	4	4dqf_017_B_101 PDB CREDO	0.583	0.200	0.503	0.010
Rv3521.2	3	3ols_EST_A_600 PDB CREDO	0.566	0.222	0.503	0.010
Rv3521.2	3	3tbg_RTZ_A_1 PDB CREDO	0.614	0.162	0.503	0.010
Rv3521.2	4	2r5q_1UN_B_900 PDB CREDO	0.765	0.040	0.503	0.010
Rv3521.2	4	2r5q_1UN_D_900 PDB CREDO	0.765	0.040	0.503	0.010
Rv3521.2	4	3ekv_478_A_200 PDB CREDO	0.582	0.201	0.503	0.010
Rv3521.2	4	1err_RAL_A_600 PDB CREDO	0.862	0.008	0.502	0.011
Rv3521.2	4	3pww_ROC_A_1001 PDB CREDO	0.628	0.147	0.501	0.011
Rv3521.2	3	1mx1_THA_A_1 PDB CREDO	0.612	0.165	0.501	0.011
Rv3521.2	4	2jfa_RAL_A_600 PDB CREDO	0.886	0.004	0.501	0.011
Rv3521.2	4	3em3_478_B_200 PDB CREDO	0.580	0.204	0.501	0.011
Rv3521.2	4	2oiq_STI_A_1001 PDB CREDO	0.808	0.022	0.500	0.011
Rv3521.2	4	3oxv_478_C_200 PDB CREDO	0.627	0.149	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions