Rv2703

Tuberculist information
Gene namesigA
Protein functionRNA polymerase sigma factor SigA (sigma-A)
Functional category(tuberculist)information pathways
Gene location(kb)3017.83
Molecular mass(da)57768.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 528
	  		  	1    VAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKP   60
			  	61   ASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVE  120
			  	121  ELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPG  180
			  	181  QTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL  240
			  	241  LNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANL  300
			  	301  RLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMA  360
			  	361  DQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREP  420
			  	421  ISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFG  480
			  	481  LTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD

Known structures in the PDB
PDB ID3I7T
Total residue count149
Number of chains1
MethodX-RAY
Resolution1.93
1 53 105 157 209 261 313 365 417 469 521 Range: 225 to 261  |  Coverage: 6% Sigma70_r1_2 Range: 295 to 365  |  Coverage: 13% Sigma70_r2 Range: 374 to 451  |  Coverage: 14% Sigma70_r3 Range: 463 to 516  |  Coverage: 10% Sigma70_r4 Range: 179 to 528  |  Coverage: 66% 1 Range: 182 to 528  |  Coverage: 65% 1 Range: 295 to 361  |  Coverage: 12% 2 Range: 64 to 362  |  Coverage: 56% 3 Range: 445 to 528  |  Coverage: 15% 4 Range: 365 to 442  |  Coverage: 14% 5
Number of amino acids : 528
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sigma70_r1_2PF00140225-261
Sigma70_r2PF04542295-365
Sigma70_r3PF04539374-451
Sigma70_r4PF04545463-516
Mtb Structural Proteome models
Model Number1
Model nameRv2703
Template2A6H    FPDBCREDO
Template coverage74_423
Template Identity(%)43.8
Model coverage(%)66.1
Normalized DOPE score0.742

Structure Models from Chopin
Model Number1
Profilea.177.1.1, a.4.13.1, a.4.13.2 - 1.10.10.10
Click for model details
zscore67.05
Residue begin182
Residue end528
Model Number2
Profilea.177.1.1 - 1.10.601.10
Click for model details
zscore29.42
Residue begin295
Residue end361
Model Number3
Profilea.177.1.1 - 1.10.601.10
Click for model details
zscore22.28
Residue begin64
Residue end362
Model Number4
Profilea.4.13.2 - 1.10.10.10
Click for model details
zscore9.15
Residue begin445
Residue end528
Model Number5
Profilea.4.13.1
Click for model details
zscore8.63
Residue begin365
Residue end442
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2703Gene nameConfidence Score
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv0667rpoB0.993
Rv2343cdnaG0.984
Rv2343cdnaG0.984
Rv2343cdnaG0.984
Rv2343cdnaG0.984
Rv2343cdnaG0.984
Rv3457crpoA0.974
Rv3457crpoA0.974
Rv3457crpoA0.974
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0350dnaK0.935
Rv3223csigH0.932
Rv3223csigH0.932
Rv0005gyrB0.921
Rv0005gyrB0.921
Rv0005gyrB0.921
Rv0005gyrB0.921
Rv2069sigC0.911
Rv2069sigC0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
rifampicinPubChem0.866822.94
isoniazidPubChem0.823137.139