Rv3490

Tuberculist information
Gene nameotsA
Protein functionAlpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase)
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)3908.24
Molecular mass(da)55862.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 500
	  		  	1    MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRR   60
			  	61   RRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLY  120
			  	121  HDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLT  180
			  	181  IGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRG  240
			  	241  TVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRKILL  300
			  	301  GVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVESYQTLRNDIERQVG  360
			  	361  HINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLG  420
			  	421  GALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDV  480
			  	481  DRWAQSFLDALAGAHPRGQG

Known structures in the PDB
No Known structures
1 51 101 151 201 251 301 351 401 451 501 Range: 20 to 493  |  Coverage: 94% Glyco_transf_20 Range: 20 to 497  |  Coverage: 95% 1 Range: 20 to 497  |  Coverage: 95% 1 Range: 13 to 289  |  Coverage: 55% 2
Number of amino acids : 500
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Glyco_transf_20PF0098220-493
Mtb Structural Proteome models
Model Number1
Model nameRv3490
Template1UQU    APDBCREDO
Template coverage1_456
Template Identity(%)33.9
Model coverage(%)95.4
Normalized DOPE score-1.019

Structure Models from Chopin
Model Number1
Profilec.87.1.6
Click for model details
zscore71.25
Residue begin20
Residue end497
Model Number2
Profile3.40.50.2000
Click for model details
zscore17.23
Residue begin13
Residue end289
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3490Gene nameConfidence Score
Rv3372otsB20.999
Rv0126treS0.984
Rv0126treS0.984
Rv1562ctreZ0.979
Rv1562ctreZ0.979
Rv0993galU0.977
Rv1563ctreY0.975
Rv1326cglgB0.963
Rv1326cglgB0.963
Rv1326cglgB0.963
Rv2402Rv24020.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-glucosePubChem0.997566.302
glucose-6-phosphatePubChem0.997260.136
trehalose-6-phosphatePubChem0.992422.276
trehalosePubChem0.983342.296
uridine diphosphatePubChem0.968404.161
UDP-GlcPubChem0.963566.302
alpha-D-glucose 6-phosphatePubChem0.963260.136
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
GDP-glucosePubChem0.768605.341
GDP-mannosePubChem0.703605.341