Rv1563c

Tuberculist information
Gene nametreY
Protein functionMaltooligosyltrehalose synthase TreY
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)1767.14
Molecular mass(da)82706.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 765
	  		  	1    MAFPVISTYRVQMRGRSNGFGFTFADAENLLDYLDDLGVSHLYLSPILTAVGGSTHGYDV   60
			  	61   TDPTTVSPELGGSDGLARLSAAARSRGMGLIVDIVPSHVGVGKPEQNAWWWDVLKFGRSS  120
			  	121  AYAEFFDIDWELGDGRIILPLLGSDSDVANLRVDGDLLRLGDLALPVAPGSGDGTGPAVH  180
			  	181  DRQHYRLVGWRHGLCGYRRFFSITSLAGLRQEDRAVFDASHAEVARWFTEGLVDGVRVDH  240
			  	241  LDGLSDPSGYLAQLRELLGPNAWIVVEKILAVDEALEPTLPVDGSTGYDVLREIGGVLVD  300
			  	301  PQGESPLTALVESAGVDYQEMPAMLADLKVHAAVHTLASELRRLRRCIAAAAGADHPLLP  360
			  	361  AAVAALLRHIGRYRCDYPGQAAVLPCALAETHSTTPQLAPGLQLIAAAVARGGEPAVRLQ  420
			  	421  QLCGAVSAKAVEDCMFYRDARLVSLNEVGGEPRRFGVGAAEFHHRAATRARLWPRSMTTL  480
			  	481  STHDTKRGEDVRARIGVLSQVPWLWAKFIGHAQAIAPAPDAVTGQFLWQNVFGVWPVSGE  540
			  	541  VSAALRGRLHTYAEKAIREAAWHTSWHNPNRAFEDDVHGWLDLVLDGPLASELTGLVAHL  600
			  	601  NSHAESDALAAKLLALTVPGVPDVYQGSELWDDSLVDPDNRRPVDYGTRRVALKALQHPK  660
			  	661  IRVLAAALRLRRTHPESFLGGAYHPVFAAGPAADHVVAFRRGDDILVAVTRWTVRLQQTG  720
			  	721  WDHTVLPLPDGSWTDALTGFTASGHTPAVELFADLPVVLLVRDNA

Known structures in the PDB
No Known structures
1 77 153 229 305 381 457 533 609 685 761 Range: 27 to 131  |  Coverage: 13% Alpha-amylase Range: 7 to 751  |  Coverage: 97% 1 Range: 4 to 762  |  Coverage: 99% 1 Range: 96 to 213  |  Coverage: 15% 2 Range: 501 to 597  |  Coverage: 12% 3 Range: 321 to 429  |  Coverage: 14% 4 Range: 1 to 765  |  Coverage: 99% 5
Number of amino acids : 765
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Alpha-amylasePF0012827-131
Mtb Structural Proteome models
Model Number1
Model nameRv1563c
Template1IV8    APDBCREDO
Template coverage4_713
Template Identity(%)33.0
Model coverage(%)97.3
Normalized DOPE score0.341

Structure Models from Chopin
Model Number1
Profileb.71.1.1, c.1.8.1 - 1.10.10.470, 1.10.150.200, 2.60.40.1180, 3.20.20.80, 3.30.1590.10
Click for model details
zscore99.34
Residue begin4
Residue end762
Model Number2
Profile3.30.1590.10
Click for model details
zscore23.32
Residue begin96
Residue end213
Model Number3
Profile1.10.10.470
Click for model details
zscore18.88
Residue begin501
Residue end597
Model Number4
Profile1.10.150.200
Click for model details
zscore11.58
Residue begin321
Residue end429
Model Number5
Profilec.1.8.1
Click for model details
zscore8.58
Residue begin1
Residue end765
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1563cGene nameConfidence Score
Rv1562ctreZ0.999
Rv1562ctreZ0.999
Rv1564ctreX0.999
Rv1564ctreX0.999
Rv1781cmalQ0.993
Rv3490otsA0.975
Rv1327cglgE0.971
Rv1327cglgE0.971
Rv0126treS0.945
Rv0126treS0.945
Rv1326cglgB0.93
Rv1326cglgB0.93
Rv1326cglgB0.93
Rv3372otsB20.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
trehalosePubChem0.873342.296
glycerolPubChem0.72592.0938