Rv1562c

Tuberculist information
Gene nametreZ
Protein functionMaltooligosyltrehalose trehalohydrolase TreZ
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)1765.4
Molecular mass(da)64076.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 580
	  		  	1    MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADARYGYLLDDDPTVLPDPR   60
			  	61   SARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYELHIGTFTTAGTFDAAIEK  120
			  	121  LDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPYGGPDGLVRFIDACHARRLGV  180
			  	181  LIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAGADSDEVRHYIIDCALRWMRDFH  240
			  	241  ADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLGRPLSLIAETDRNDPRLITRPSHGG  300
			  	301  YGITAQWNDDIHHAIHTAVSGERQGYYADFGSLATLAYTLRNGYFHAGTYSSFRRRRHGR  360
			  	361  ALDTSAIPATRLLAYTCTHDQVGNRALGDRPSQYLTGGQLAIKAALTLGSPYTAMLFMGE  420
			  	421  EWGASSPFQFFCSHPEPELAHSTVAGRKEEFAEHGWAADDIPDPQDPQTFQRCKLNWAEA  480
			  	481  GSGEHARLHRFYRDLIALRHNEADLADPWLDHLMVDYDEQQRWVVMRRGQLMIACNLGAE  540
			  	541  PTCVPVSGELVLAWESPIIGDNSTELAAYSLAILRAAEPA

Known structures in the PDB
No Known structures
1 59 117 175 233 291 349 407 465 523 581 Range: 112 to 219  |  Coverage: 18% Alpha-amylase Range: 491 to 574  |  Coverage: 14% DUF3459 Range: 2 to 575  |  Coverage: 98% 1 Range: 492 to 574  |  Coverage: 14% 1
Number of amino acids : 580
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Alpha-amylasePF00128112-219
DUF3459PF11941491-574
Mtb Structural Proteome models
Model Number1
Model nameRv1562c
Template1EH9    APDBCREDO
Template coverage11_557
Template Identity(%)38.8
Model coverage(%)98.8
Normalized DOPE score-0.19

Structure Models from Chopin
Model Number1
Profile3.30.457.10
Click for model details
zscore4.52
Residue begin492
Residue end574
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1562cGene nameConfidence Score
Rv1563ctreY0.999
Rv1564ctreX0.993
Rv1564ctreX0.993
Rv1781cmalQ0.989
Rv3490otsA0.979
Rv1327cglgE0.974
Rv1327cglgE0.974
Rv1213glgC0.958
Rv1213glgC0.958
Rv0126treS0.941
Rv0126treS0.941
Rv1326cglgB0.913
Rv1326cglgB0.913
Rv1326cglgB0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
trehalosePubChem0.994342.296
neotrehalosePubChem0.9342.296
magnesiumPubChem0.81424.305
triethylene glycolPubChem0.782150.173