Rv1327c

Tuberculist information
Gene nameglgE
Protein functionProbable glucanase GlgE
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1492.32
Molecular mass(da)78607.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 701
	  		  	1    VSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVSAAVWREGHEAVAATL   60
			  	61   VVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEPFVFHGQFTPDRVGLWT  120
			  	121  FRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLERAATGVPRGLRDPLLAAA  180
			  	181  AALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGVWVDRPLARFGAWYEMFPR  240
			  	241  STGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHPIGKVHRKGRNNSPTAAPTD  300
			  	301  VGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEVALDLALQCAPDHPWAREHR  360
			  	361  QWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDEVLRVVQHWVNHGVKFFRVDNP  420
			  	421  HTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGLAKLGFTQSYSYFTWRTTKWELT  480
			  	481  EFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMFAIRAVLAATMSPAWGMYCGYELF  540
			  	541  EHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQPFITRLNIIRRLHPAFQQLRTIHF  600
			  	601  HHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEEATLWLDMAALGMEDYDRFWVRDEIT  660
			  	661  GEEYQWGQANYIRIDPARAVAHIINMPAVPYESRNTLLRRR

Known structures in the PDB
No Known structures
1 71 141 211 281 351 421 491 561 631 701 Range: 14 to 227  |  Coverage: 30% DUF3416 Range: 254 to 476  |  Coverage: 31% Alpha-amylase Range: 103 to 694  |  Coverage: 84% 1 Range: 254 to 476  |  Coverage: 31% 1
Number of amino acids : 701
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF3416PF1189614-227
Alpha-amylasePF00128254-476
Mtb Structural Proteome models
Model Number1
Model nameRv1327c
Template1WZL    APDBCREDO
Template coverage19_585
Template Identity(%)15.7
Model coverage(%)84.3
Normalized DOPE score0.627

Structure Models from Chopin
Model Number1
Profilec.1.8.1
Click for model details
zscore14.14
Residue begin254
Residue end476
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1327cGene nameConfidence Score
Rv0127mak0.991
Rv1326cglgB0.987
Rv1326cglgB0.987
Rv1326cglgB0.987
Rv1564ctreX0.982
Rv1564ctreX0.982
Rv1562ctreZ0.974
Rv1562ctreZ0.974
Rv1563ctreY0.971
Rv1328glgP0.931
Rv1328glgP0.931
Rv0126treS0.925
Rv0126treS0.925
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions