Rv1564c

Tuberculist information
Gene nametreX
Protein functionProbable maltooligosyltrehalose synthase TreX
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)1769.44
Molecular mass(da)81081.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 721
	  		  	1    MSSNNAGESDGTGPALPTVWPGNAYPLGATYDGAGTNFSLFSEIAEKVELCLIDEDGVES   60
			  	61   RIPLDEVDGYVWHAYLPNITPGQRYGFRVHGPFDPAAGHRCDPSKLLLDPYGKSFHGDFT  120
			  	121  FGQALYSYDVNAVDPDSTPPMVDSLGHTMTSVVINPFFDWAYDRSPRTPYHETVIYEAHV  180
			  	181  KGMTQTHPSIPPELRGTYAGLAHPVIIDHLNELNVTAVELMPVHQFLHDSRLLDLGLRNY  240
			  	241  WGYNTFGFFAPHHQYASTRQAGSAVAEFKTMVRSLHEAGIEVILDVVYNHTAEGNHLGPT  300
			  	301  INFRGIDNTAYYRLMDHDLRFYKDFTGTGNSLNARHPHTLQLIMDSLRYWVIEMHVDGFR  360
			  	361  FDLASTLARELHDVDRLSAFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPGLWTEWN  420
			  	421  GKYRDTVRDYWRGEPATLGEFASRLTGSSDLYEATGRRPSASINFVTAHDGFTLNDLVSY  480
			  	481  NDKHNEANGENNRDGESYNRSWNCGVEGPTDDPDILALRARQMRNMWATLMVSQGTPMIA  540
			  	541  HGDEIGRTQYGNNNVYCQDSELSWMDWSLVDKNADLLAFARKATTLRKNHKVFRRRRFFE  600
			  	601  GEPIRSGDEVRDIAWLTPSGREMTHEDWGRGFDRCVAVFLNGEAITAPDARGERVVDDSF  660
			  	661  LLCFNAHDHDVEFVMPHDGYAQQWTGELDTNDPVGDIDLTVTATDTFSVPARSLLVLRKT  720
			  	721  L

Known structures in the PDB
No Known structures
1 73 145 217 289 361 433 505 577 649 721 Range: 26 to 112  |  Coverage: 11% CBM_48 Range: 205 to 553  |  Coverage: 48% Alpha-amylase Range: 23 to 717  |  Coverage: 96% 1 Range: 205 to 553  |  Coverage: 48% 1 Range: 1 to 721  |  Coverage: 99% 2
Number of amino acids : 721
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CBM_48PF0292226-112
Alpha-amylasePF00128205-553
Mtb Structural Proteome models
Model Number1
Model nameRv1564c
Template1BF2    APDBCREDO
Template coverage3_747
Template Identity(%)34.0
Model coverage(%)96.1
Normalized DOPE score-0.378

Structure Models from Chopin
Model Number1
Profilec.1.8.1
Click for model details
zscore16.23
Residue begin205
Residue end553
Model Number2
Profilec.1.8.1
Click for model details
zscore11.26
Residue begin1
Residue end721
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1564cGene nameConfidence Score
Rv1563ctreY0.999
Rv1213glgC0.997
Rv1213glgC0.997
Rv1781cmalQ0.995
Rv1562ctreZ0.993
Rv1562ctreZ0.993
Rv1327cglgE0.982
Rv1327cglgE0.982
Rv1326cglgB0.982
Rv1326cglgB0.982
Rv1326cglgB0.982
Rv1328glgP0.923
Rv1328glgP0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
maltotetraosePubChem0.921666.578
mannanPubChem0.911666.578
alpha-D-glucosePubChem0.826198.171
glycogenPubChem0.822666.578
galactosePubChem0.806180.156
hydron sulfatePubChem0.788196.157
sulfatePubChem0.78896.0626
amylopectinPubChem0.752828.718
trehalosePubChem0.72342.296
glycerolPubChem0.71692.0938
Daf-(1-4)glcPubChem0.708485.48