Tuberculist information
Gene namemalQ
Protein functionProbable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2015.3
Molecular mass(da)79745
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 724
	  		  	1    MTELAPSLVELARRFGIATEYTDWTGRQVLVSEATLVAALAALGVPAQTEQQRNDALAAQ   60
			  	61   LRSYWARPLPATIVMRAGEQTQFRVHVTDGAPADVWLQLEDGTTRAEVVQVDNFTPPFDL  120
			  	121  DGRWIGEASFVLPADLPLGYHRVNLRSGDSQASAAVVVTPDWLGLPDKLAGRRAWGLAVQ  180
			  	181  LYSVRSRQSWGIGDLTDLANLALWSASAHGAGYVLVNPLHAATLPGPAGRSKPIEPSPYL  240
			  	241  PTSRRFVNPLYLRVEAIPELVDLPKRGRVQRLRTNVQQHADQLDTIDRDSAWAAKRAALK  300
			  	301  LVHRVPRSAGRELAYAAFRTREGRALDDFATWCALAETYGDDWHRWPKSLRHPDASGVAD  360
			  	361  FVDKHADAVDFHRWLQWQLDEQLASAQSQALRAGMSLGIMADLAVGVHPNGADAWALQDV  420
			  	421  LAQGVTAGAPPDEFNQLGQDWSQPPWRPDRLAEQEYRPFRALIQAALRHAGAVRIDHIIG  480
			  	481  LFRLWWIPDGAPPTQGTYVRYDHDAMIGIVALEAHRAGAVVVGEDLGTVEPWVRDYLLLR  540
			  	541  GLLGTSILWFEQDRDCGPAGTPLPAERWREYCLSSVTTHDLPPTAGYLAGDQVRLRESLG  600
			  	601  LLTNPVEAELESARADRAAWMAELRRVGLLADGAEPDSEEAVLALYRYLGRTPSRLLAVA  660
			  	661  LTDAVGDRRTQNQPGTTDEYPNWRVPLTGPDGQPMLLEDIFTDRRAATLAEAVRAATTSP  720
			  	721  MSCW
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Glyco_hydro_77PF02446179-714
Mtb Structural Proteome models
Model Number1
Model nameRv1781c
Template1ESW    APDBCREDO
Template coverage4_496
Template Identity(%)28.6
Model coverage(%)74.6
Normalized DOPE score0.127

Structure Models from Chopin
Model Number1
Profilec.1.8.1 - 3.20.20.80
Click for model details
zscore37.03
Residue begin45
Residue end724
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1781cGene nameConfidence Score
Rv1564ctreX0.995
Rv1564ctreX0.995
Rv1563ctreY0.993
Rv1562ctreZ0.989
Rv1562ctreZ0.989
Rv1326cglgB0.954
Rv1326cglgB0.954
Rv1326cglgB0.954
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
maltotriosePubChem0.965504.437
beta-glucanPubChem0.961504.437
maltotetraosePubChem0.943666.578
alpha-D-glucosePubChem0.939198.171
galactosePubChem0.931180.156
mannanPubChem0.93666.578
adenosine triphosphatePubChem0.904507.181
lactosePubChem0.903342.296
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
beta-D-glucosePubChem0.9180.156
glucose-6-PPubChem0.9260.136
deuteriumPubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
4-O-alpha-D-glucopyranosyl-D-glucosePubChem0.9342.296
glucose-6-phosphatePubChem0.9260.136
protiumPubChem0.92.01576