Rv1328

Tuberculist information
Gene nameglgP
Protein functionProbable glycogen phosphorylase GlgP
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1494.56
Molecular mass(da)95483.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 863
	  		  	1    VKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPALWEQCGHDPVALLGA   60
			  	61   VNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGVAAQALPTGIAYFSLEF  120
			  	121  GVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYFRQSLTADGWQHETYPSL  180
			  	181  DPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRVPLLLLDSDIPENEHDLRN  240
			  	241  VTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPEVFHMNEGHAGFLGIERIRE  300
			  	301  LVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMVQRYVNDQRGDGRSRLLPGLP  360
			  	361  ADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRVSRAMFNELWAGFDPDEVPIGS  420
			  	421  VTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLHQVDPAHLWWIRSQLRSMLVEDV  480
			  	481  RARLRQSWLERGATDAELGWIATAFDPNVLTVGFARRVPTYKRLTLMLRDPDRLEQLLLD  540
			  	541  EQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQVRHRIAFLPNYDMSMARLLYWGCDV  600
			  	601  WLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWDEWYDGENGWEIPSADGVADENRRDD  660
			  	661  LEAGALYDLLAQAVAPKFYERDERGVPQRWVEMVRHTLQTLGPKVLASRMVRDYVEHYYA  720
			  	721  PAAQSFRRTAGAQFDAARELADYRRRAEEAWPKIEIADVDSTGLPDTPLLGSQLTLTATV  780
			  	781  RLAGLRPNDVTVQGVLGRVDAGDVLMDPVTVEMAHTGTGDGGYEIFSTTTPLPLAGPVGY  840
			  	841  TVRVLPRHPMLAASNELGLVTLA

Known structures in the PDB
No Known structures
1 87 173 259 345 431 517 603 689 775 861 Range: 3 to 126  |  Coverage: 14% DUF3417 Range: 229 to 639  |  Coverage: 47% Phosphorylase Range: 2 to 787  |  Coverage: 90% 1 Range: 36 to 764  |  Coverage: 84% 2 Range: 7 to 803  |  Coverage: 92% 3 Range: 1 to 64  |  Coverage: 7% 1 Range: 125 to 188  |  Coverage: 7% 2 Range: 229 to 292  |  Coverage: 7% 3
Number of amino acids : 863
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF3417PF118973-126
PhosphorylasePF00343229-639
Mtb Structural Proteome models
Model Number1
Model nameRv1328.1
Template1YGP    APDBCREDO
Template coverage25_829
Template Identity(%)20.4
Model coverage(%)91.0
Normalized DOPE score0.251

Model Number2
Model nameRv1328
Template1L5W    APDBCREDO
Template coverage32_777
Template Identity(%)21.7
Model coverage(%)84.4
Normalized DOPE score0.318

Model Number3
Model nameRv1328.2
Template1C8K    APDBCREDO
Template coverage13_840
Template Identity(%)19.6
Model coverage(%)92.2
Normalized DOPE score0.757

Structure Models from Chopin
Model Number1
Profilec.87.1.4
Click for model details
zscore8.09
Residue begin1
Residue end64
Model Number2
Profilec.87.1.4
Click for model details
zscore8.09
Residue begin125
Residue end188
Model Number3
Profilec.87.1.4
Click for model details
zscore8.09
Residue begin229
Residue end292
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1328Gene nameConfidence Score
Rv1326cglgB0.999
Rv1326cglgB0.999
Rv1326cglgB0.999
Rv1213glgC0.997
Rv1213glgC0.997
Rv3068cpgmA0.983
Rv3068cpgmA0.983
Rv3068cpgmA0.983
Rv3068cpgmA0.983
Rv1327cglgE0.931
Rv1327cglgE0.931
Rv3257cpmmA0.924
Rv3257cpmmA0.924
Rv3257cpmmA0.924
Rv3257cpmmA0.924
Rv1564ctreX0.923
Rv1564ctreX0.923
Rv0993galU0.907
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv1328.183bjw_SVR_B_501PDBCREDO0.7120.0720.5220.008
Rv1328.183bjw_SVR_H_504PDBCREDO0.7080.0750.5190.008
Rv1328.183bjw_SVR_F_502PDBCREDO0.7070.0760.5180.008
Rv1328.182xkw_P1B_A_1478PDBCREDO0.6870.0910.5170.008
Rv1328.181tco_FK5_C_509PDBCREDO0.6680.1070.5030.010
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.98260.136
glycogenPubChem0.961666.578
maltotetraosePubChem0.942666.578
phosphatePubChem0.9496.9872
mannanPubChem0.932666.578
hydroxyl radicalsPubChem0.90917.0073
maltoheptaosePubChem0.7311153