Rv0536

Tuberculist information
Gene namegalE3
Protein functionProbable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)627.248
Molecular mass(da)36219.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 346
	  		  	1    MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVLPPGCQRVDVRDASALA   60
			  	61   PLLAGVDLVCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVRRLVLASSMVVY  120
			  	121  GQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASK  180
			  	181  TAQEHYALAWSEASGGSVVALRYHNVYGPGMPRDTPYSGVAAIFRSAVEKGKPPKVFEDG  240
			  	241  GQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSP  300
			  	301  AITGHYRSGDVRHIVADPARAARVLGFRAAVDPGEGLREFAFAPLR

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 3 to 276  |  Coverage: 78% Epimerase Range: 1 to 346  |  Coverage: 99% 1 Range: 223 to 346  |  Coverage: 35% 1 Range: 1 to 346  |  Coverage: 99% 2
Number of amino acids : 346
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EpimerasePF013703-276
Mtb Structural Proteome models
Model Number1
Model nameRv0536
Template1UDB    APDBCREDO
Template coverage1_331
Template Identity(%)26.9
Model coverage(%)99.7
Normalized DOPE score0.266

Structure Models from Chopin
Model Number1
Profile3.90.25.10
Click for model details
zscore9.99
Residue begin223
Residue end346
Model Number2
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore9.4
Residue begin1
Residue end346
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0536Gene nameConfidence Score
Rv0322udgA0.954
Rv0322udgA0.954
Rv0322udgA0.954
Rv0993galU0.935
Rv0619galTb0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-glucosePubChem0.935566.302
NAD+PubChem0.934663.425
UDP-galactosePubChem0.915566.302
uridine diphosphatePubChem0.913404.161
glucose-1-phosphatePubChem0.912260.136
reduced nicotinamide adenine dinucleotidePubChem0.911665.441
UDP-GlcPubChem0.909566.302
fructosePubChem0.907180.156
galactose-1-phosphatePubChem0.907336.316
uridine diphosphate galactosePubChem0.906566.302
UDPGAPubChem0.901580.285
UDP-4-keto-6-deoxy-D-glucosePubChem0.9548.286
CPD-663PubChem0.9548.286
pyrophosphatePubChem0.9177.975
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
uridine triphosphatePubChem0.9484.141
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
sucrosePubChem0.9342.296
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588