SInCRe - Rv3634c

Tuberculist information

Gene name	galE1
Protein function	UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	4072.67
Molecular mass(da)	33549.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 314

	  		  	1    VRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTA   60
			  	61   DLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTS  120
			  	121  SGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPR  180
			  	181  QDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNI  240
			  	241  GTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDIGLAERVLGWRPQIELADG  300
			  	301  VRRTVEYFRHKHTD

Known structures in the PDB

No Known structures

Number of amino acids : 314

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Epimerase	PF01370	3-241

Mtb Structural Proteome models

Model Number	1
Model name	Rv3634c
Template	1R6D APDB CREDO
Template coverage	1_316
Template Identity(%)	34.5
Model coverage(%)	99.4
Normalized DOPE score	-0.764

Structure Models from Chopin

Model Number	1
Profile	c.2.1.2 - 3.40.50.720 Click for model details
zscore	12.55
Residue begin	1
Residue end	314

Model Number	2
Profile	3.90.25.10 Click for model details
zscore	10.02
Residue begin	173
Residue end	314

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3634c	Gene name	Confidence Score
Rv3465	rmlC	0.994
Rv0334	rmlA	0.993
Rv0322	udgA	0.991
Rv0322	udgA	0.991
Rv0322	udgA	0.991
Rv0993	galU	0.989
Rv0619	galTb	0.941
Rv3266c	rmlD	0.939
Rv0618	galTa	0.911

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
UDP-glucosePubChem	0.954	566.302
UDP-galactosePubChem	0.928	566.302
glucose-1-phosphatePubChem	0.923	260.136
deoxythymidine diphosphate-glucosePubChem	0.923	564.329
dTDP-glucosePubChem	0.922	564.329
TDP-4-keto-6-deoxy-d-glucosePubChem	0.908	546.314
dTDP-4-amino-4,6-dideoxy-D-glucosePubChem	0.902	547.345
thymidine triphosphatePubChem	0.901	482.168
dTDP-4-keto-L-rhamnosePubChem	0.9	546.314
TDP-FucNPubChem	0.9	546.337
pyrophosphatePubChem	0.9	177.975
H(+)PubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
deuteriumPubChem	0.9	2.01588
dTDP-4-dehydro-L-rhamnosePubChem	0.9	544.298
hydroxyl radicalsPubChem	0.9	17.0073
alpha-ketoglutaratePubChem	0.9	146.098
TDP-alpha-GPubChem	0.9	564.329
glutamatePubChem	0.9	147.129
NAD+PubChem	0.809	663.425